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SCP0159

Sigma-Aldrich

Granzyme B Substrate / Caspase 3 Processing Enzyme Substrate / Caspase 8 Processing Enzyme Substrate

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Empirical Formula (Hill Notation):
C33H42N6O13
Molecular Weight:
730.72

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥85%

storage condition

protect from light

storage temp.

−20°C

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Caspase 1 Substrate

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SCP0071

Caspase 1 Substrate

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SCP0158

Granzyme B Substrate

form

lyophilized

form

lyophilized

form

lyophilized

form

lyophilized

storage condition

protect from light

storage condition

protect from light

storage condition

protect from light

storage condition

protect from light

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

composition

Peptide Content, ≥85%

composition

Peptide Content, ≥87%

composition

Peptide Content, ≥80%

composition

Peptide Content, ≥85%

Amino Acid Sequence

Z-Ile-Glu-Thr-Asp-pNA

Application

Caspase 8 Processing Enzyme Substrate (Z-Ile-Glu-Thr-Asp-pNA; zIETD-pNa) is used as a substrate to identify, differentiate and characterize Granzyme B, Caspase 3 Processing Enzyme(s) and Caspase 8 Processing enzyme(s). Z-Ile-Glu-Thr-Asp-pNA is closely related to Z-Ile-Glu-Thr-Asp-fluoromethylketone (zIETD-fmk), an inhibitor of Caspase 8.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Mohammed W Al-Rabia et al.
Journal of leukocyte biology, 75(6), 1045-1055 (2004-04-13)
Caspases are key molecules in the control of apoptosis, but relatively little is known about their contribution to eosinophil apoptosis. We examined caspase-3, -8, and -9 activities in receptor ligation-dependent apoptosis induction in the differentiated human eosinophilic cell line EoL-1.
Christopher E Jenkins et al.
The Journal of biological chemistry, 279(35), 37201-37207 (2004-06-19)
Mast cells play an important role in both allergy and innate immunity. Recently, we demonstrated an active interaction between human mast cells and Pseudomonas aeruginosa leading to the production of multiple cytokines. Here, we show that both primary cultured human
W D Thomas et al.
Journal of immunology (Baltimore, Md. : 1950), 165(10), 5612-5620 (2000-11-09)
Past studies have shown that TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis in a high proportion of cultured melanoma by caspase-dependent mechanisms. In the present studies we have examined whether TRAIL-induced apoptosis of melanoma was mediated by direct activation of effector

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