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T2815

Sigma-Aldrich

Transforming Growth Factor-β2 human

TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture

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Synonym(s):
hTGF-β2, TGF-β2
MDL number:
NACRES:
NA.77

biological source

human

Quality Level

recombinant

expressed in NSO cells

Assay

≥97% (electrophoresis)

form

powder

potency

0.04 ng/mL ED50

quality

endotoxin tested

mol wt

25 kDa

packaging

pkg of 10 μg
pkg of 2 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

suitability

suitable for

UniProt accession no.

storage temp.

−20°C

Gene Information

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This Item
H8666T7039H8541
recombinant

expressed in NSO cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in CHO cells

recombinant

expressed in HEK 293 cells

assay

≥97% (electrophoresis)

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

form

powder

form

lyophilized powder

form

powder

form

lyophilized powder

potency

0.04 ng/mL ED50

potency

≤0.5 ng/mL EC50

potency

≤0.05 ng/mL ED50

potency

≤0.5 ng/mL EC50

mol wt

25 kDa

mol wt

dimer 25 kDa (non-glycosylated)

mol wt

protein 25 kDa

mol wt

dimer 25 kDa (non-glycosylated)

General description

The transforming growth factor-β2 (TGFB2) gene is mapped to human chromosome 1q41. The encoded protein is localized to extracellular matrix. TGF-β2 is a member of the TGF-β superfamily. TGF-β exists in three isoforms (TGF-β1, TGF-β2 and TGF-β3) and are known to share similar structure and function.

Application

Transforming Growth Factor-β2 human has been used in chondrogenic, adipogenic and osteogenic differentiation of mesenchymal stem cells. It has also been used to induce extracellular matrix accumulation in primary human trabecular meshwork cells and further to study the action of tetramethylpyrazine on the same.

Biochem/physiol Actions

TGF-β2 is known to stimulate cell growth, differentiation, migration and survival. TGF-β2 acts as a key regulator for immune homeostasis by controlling lymphocyte proliferation, embryogenesis, hematopoiesis and apoptosis. TGF-β is also associated with inflammation and wound healing and is considered as a strong growth inhibitor for keratinocyte cells. TGF-β is associated with the process of tumor development, progression and metastasis. TGF-β2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. The TGF-β gene is overexpressed in glioma tumors and also in colon cancer, gastric cancer and cervical lesions.
Transforming growth factor-β2 (TGF-β2), like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.1 mg bovine serum albumin

Analysis Note

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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