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GF113

Sigma-Aldrich

Transforming Growth Factor-β2 Protein, Recombinant human

Transforming Growth Factor-beta2 (TGF-beta2) is a member of a superfamily of homologous, disulfide-linked, homodimeric proteins that regulate the proliferation & differentiation of normal & transformed cells.

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Synonym(s):
TGF-beta2
eCl@ss:
32160405
NACRES:
NA.75

biological source

human

Quality Level

assay

>95% (SDS-PAGE)

specific activity

≥5 x 10e6 U/mg

manufacturer/tradename

Chemicon®

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 ng/μg Endotoxin (of TGF-Beta2; 1EU/ug)

input

sample type mesenchymal stem cell(s)

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Gene Information

human ... TGFB2(7042)

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This Item
H8666T2815T7039
biological source

human

biological source

human

biological source

human

biological source

human

assay

>95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥97% (electrophoresis)

assay

≥98% (SDS-PAGE)

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 ng/μg Endotoxin (of TGF-Beta2; 1EU/ug)

impurities

≤1 EU/μg

impurities

≤1 EU/μg

impurities

<1 EU/μg

Gene Information

human ... TGFB2(7042)

Gene Information

human ... TGFB2(7042)

Gene Information

human ... TGFB2(7042), TGFBR2(7048)

Gene Information

human ... TGFB1(7040)

General description

Product Source: Baculovirus infected High-5 cells
Transforming Growth Factor- beta2 (TGF-beta2) is a member of a superfamily of homologous, disulfide-linked, homodimeric proteins that regulate the proliferation and differentiation of normal and transformed cells. Human TGF-beta2 is a 25.0 kDa protein with each subunit containing 112 amino acid residues.

Biochem/physiol Actions

Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells.The ED(50) was found to be ≤0.2ng/ml

Physical form

Lyophilized from Sodium Citrate, pH 3.5.

Storage and Stability

The lyophilized powder is stable for a few weeks at room temperature, but best stored at -20°C. Reconstitute with water to a concentration of 50 μg/ml (e.g., 5 μg/100 μl), this will yield a solution of 1 mM citrate buffer pH 3.5 This solution can then be stored at room temperature or at 2-8ºC for 1 month. It is recommended that further dilutions be made into PBS containing 2 mg/ml albumin and stored at -20ºC. Reconstituted human TGF-beta2 should be stored in undiluted aliquots at -20°C for at least 2 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Warning

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1


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Inflammasomes are protein platforms linking recognition of microbe, pathogen-associated and damage-associated molecular patterns by cytosolic sensory proteins to caspase-1 activation. Caspase-1 promotes pyroptotic cell death and the maturation and secretion of interleukin (IL)-1β and IL-18, which trigger inflammatory responses to

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