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T5905

Sigma-Aldrich

L-Thyronine

≥98.0% (TLC)

Synonym(s):

3-(p-[p-Hydroxyphenoxy]phenyl)-L-alanine

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About This Item

Empirical Formula (Hill Notation):
C15H15NO4
CAS Number:
1596-67-4
Molecular Weight:
273.28
EC Number:
216-483-8
MDL number:
MFCD00063070
UNSPSC Code:
12352202
PubChem Substance ID:
24900328
NACRES:
NA.26

product name

L-Thyronine,

assay

≥98.0% (TLC)

Quality Level

200

form

powder

SMILES string

N[C@@H](Cc1ccc(Oc2ccc(O)cc2)cc1)C(O)=O

InChI

1S/C15H15NO4/c16-14(15(18)19)9-10-1-5-12(6-2-10)20-13-7-3-11(17)4-8-13/h1-8,14,17H,9,16H2,(H,18,19)/t14-/m0/s1

InChI key

KKCIOUWDFWQUBT-AWEZNQCLSA-N

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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J Köhrle
Cellular and molecular life sciences : CMLS, 57(13-14), 1853-1863 (2001-02-24)
Thyroid hormones control growth, development, differentiation and metabolism in vertebrates. Most of the actions of the active thyroid hormone T3 (3,5,3'-triiodo-L-thyronine) are exerted via ligand-activated nuclear T3 receptors. Activation of the secretory product of the thyroid gland, L-thyroxine (3,3',5,5'-tetraiodo-L-thyronine), or
Martin A Paquette et al.
PloS one, 9(6), e101155-e101155 (2014-06-28)
Thyroid hormone (TH) exerts its effects by binding to the thyroid hormone receptor (TR), which binds to TH response elements (TREs) to regulate target gene expression. We investigated the relative ability of liganded homodimers TR and retinoid X receptor (RXR)
J S LoPresti et al.
The Journal of clinical endocrinology and metabolism, 70(5), 1479-1484 (1990-05-01)
A hidden pool of rT3 production represents a source of rT3 that is minimally reflected in circulating rT3 levels. To test for the existence of such a source of rT3 production in man, varying doses of the generalized deiodinase inhibitor
I J Chopra et al.
The Journal of clinical endocrinology and metabolism, 75(1), 189-194 (1992-07-01)
A highly sensitive, specific, and reproducible RIA has been developed to measure T3 sulfate (T3S). Only T4 sulfate cross-reacted significantly (approximately 3%) in the RIA; rT3 sulfate, T4, T3, rT3, and diiodothyronine cross-reacted less than 0.01%. T3S was bound by
D B Ramsden et al.
Biomedical mass spectrometry, 11(4), 193-198 (1984-04-01)
The mass spectral properties of four classes of derivatives of thyronine are discussed ( oxazolidinone , O-methyl oxazolidinone , O-acetyl oxazolidinone and N,O- diheptafluorobutyryl methyl ester). An assay for thyronine in human urine is described based on the N,O- diheptafluorobutyryl
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