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T9145

Sigma-Aldrich

Thyroglobulin from bovine thyroid

(For Gel Filtration Chromatography)

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Synonym(s):
Tg
CAS Number:
EC Number:
MDL number:
NACRES:
NA.56

biological source

bovine thyroid

Quality Level

form

powder

mol wt

~670 kDa

technique(s)

bioconjugation: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

cow ... TG(280706)

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This Item
A8549L9507A6043
vibrant-m

T9145

Thyroglobulin from bovine thyroid

vibrant-m

A8549

Albumin, biotin labeled bovine

vibrant-m

L9507

Lactoferrin from bovine milk

technique(s)

bioconjugation: suitable

technique(s)

bioconjugation: suitable

technique(s)

fractionation: suitable

technique(s)

bioconjugation: suitable

form

powder

form

lyophilized powder

form

powder

form

lyophilized powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

UniProt accession no.

P01267

UniProt accession no.

P02769

UniProt accession no.

P24627

UniProt accession no.

P02769

mol wt

~670 kDa

mol wt

-

mol wt

~87 kDa

mol wt

-

Application

Thyroglobulin is used for antibody purification and characterization. Thyroglobulin has been used in studies assessing the monitoring of differentiated thyroid cancer as well as to develop an accurate diagnostic tool for patients with autoimmune thyroid diseases.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Biochem/physiol Actions

Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Morgan E Abernathy et al.
NPJ vaccines, 6(1), 126-126 (2021-10-27)
HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to off-target regions of HIV-1 Env. We report characterization of Ab1245, an off-target antibody against the Env gp120-gp41 interface, from
Andrew N Hoofnagle et al.
Clinical chemistry, 54(11), 1796-1804 (2008-09-20)
Quantification of serum tumor markers plays an important role in determining whether patients treated for cancer require further therapy. Whereas large-scale proteomic efforts aim to identify novel tumor markers to facilitate early detection, optimization of methods for quantifying known tumor
Perrine Munier et al.
Annales de biologie clinique, 69(6), 721-725 (2011-11-30)
Thyroglobuline (Tg) is a large molecule of high molecular weight mainly indicated in monitoring differentiated thyroid cancer (DTC), its measurement remains difficult. We report the case of a patient who underwent total thyroidectomy for a poorly differentiated thyroid insular carcinoma.
Akio Yoshida et al.
The Journal of clinical endocrinology and metabolism, 94(2), 442-448 (2008-12-04)
Pendrin is an apical protein of thyroid follicular cells, responsible for the efflux of iodide into the follicular lumen via an iodide-chloride transport mechanism. It is unknown whether pendrin is recognized by autoantibodies. Our objective was to examine the prevalence
Kookjoo Kim et al.
Acta crystallographica. Section D, Structural biology, 77(Pt 11), 1451-1459 (2021-11-03)
Thyroglobulin is a homodimeric glycoprotein that is essential for the generation of thyroid hormones in vertebrates. Upon secretion into the lumen of follicles in the thyroid gland, tyrosine residues within the protein become iodinated to produce monoiodotyrosine (MIT) and diiodotyrosine

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