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U2625

Sigma-Aldrich

Uric acid

≥99%, crystalline

Synonym(s):

2,6,8-Trihydroxypurine

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About This Item

Empirical Formula (Hill Notation):
C5H4N4O3
CAS Number:
Molecular Weight:
168.11
Beilstein/REAXYS Number:
156158
EC Number:
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.55

Quality Level

100
200

assay

≥99%

form

crystalline

mp

>300 °C (lit.)

SMILES string

O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

InChI key

LEHOTFFKMJEONL-UHFFFAOYSA-N

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Application

Uric acid has been used:
  • in inducing hyperuricemia in mice
  • as a component of digestion fluid for the simulation of in vitro human digestion model
  • in selectivity test of the glucose sensor in sweat-based diabetes monitoring

Biochem/physiol Actions

Uric acid is an insoluble catabolite produced by adenine and guanine metabolism. Accumulation of uric acid leads to gout, hyperuricemia, arthritis and renal failure. Elevated uric acid levels contributes to hypertension and pathogenesis of cardiovascular disease. Low uric acid levels associated with Parkinson′s disease and multiple sclerosis, may elicit protective functionality. High levels of uric acid in patients with chronic obstructive pulmonary disease (COPD) may serve as potential marker for diagnosis.

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Uric acid in plants and microorganisms: Biological applications and genetics-A review
Hafez RM, et al.
Journal of Advanced Research, 8(5), 475-486 (2017)
Reduction of Serum Uric Acid Associated with Attenuation of Renal Injury, Inflammation and Macrophages M1/M2 Ratio in Hyperuricemic Mice Model
HARYONO A, et al.
Kobe J. Med. Sci., 64(3), E107-E114 (2018)
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
Lee H, et al.
Nature Nanotechnology, 11(6), 566-566 (2016)
Serum uric acid: a risk factor and a target for treatment?
Feig DI, et al.
Journal of the American Society of Nephrology, 17(4), S69-S73 (2006)
Uric acid, hyperuricemia and vascular diseases
Jin M, et al.
Frontiers in Bioscience, 17, 656-656 (2012)

Articles

Uric acid present in animal sera impacts serum-supplemented classical cell culture systems, influencing cell culture performance.

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