U3003

Uridine

powder, BioReagent, suitable for cell culture

• Synonym(s): 1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside
• Empirical Formula (Hill Notation): C₉H₁₂N₂O₆
• CAS Number: 58-96-8
• Molecular Weight: 244.20
• Beilstein/REAXYS Number: 754902
• EC Number: 200-407-5
• MDL number: MFCD00006526
• UNSPSC Code: 12352207
• PubChem Substance ID: 24900638
• NACRES: NA.75

Properties

• biological source: synthetic (organic)
• product line: BioReagent
• assay: ≥99%
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: 163-167 °C (lit.)
• solubility: H₂O: 50 mg/mL
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
• InChI: 1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
• InChI key: DRTQHJPVMGBUCF-XVFCMESISA-N
• Gene Information: mouse ... Uck1(22245)

Description

General description

Uridine is a uracil nucleoside, specific for RNA sequence. Uridine is present in blood, seminal fluid and cerebrospinal fluid. Uridine is a substrate for nucleotide synthesis in living organisms by de- novo and salvage pathways.

Application

Uridine has been used:

• as an inhibitor of schwann cell proliferation in rat dorsal root ganglia (DRG) neurons culture
• as a medium supplement for epiblasts culture
• as a component of 5-fluoro-2′-deoxyuridine stock solution used for neuronal culture

Biochem/physiol Actions

Uridine monophosphate is essential for protein glycosylation, polysaccharide biosynthesis and lipid metabolism. Oral administration of uridine is suggested for anisopoikilocytosis and epileptic encephalopathy disorders. Uridine has numerous biological functions like, treating dry eye syndrome, regulating nervous system and favors reproduction. High levels of uridine induces insulin resistance.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)