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BP1100

Hydroxychloroquine sulfate

British Pharmacopoeia (BP) Reference Standard

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Synonym(s):
7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
Empirical Formula (Hill Notation):
C18H26ClN3O · H2SO4
CAS Number:
Molecular Weight:
433.95
MDL number:

grade

pharmaceutical primary standard

agency

BP

API family

hydroxychloroquine

form

solid

packaging

pkg of 100 mg

manufacturer/tradename

BP

color

off-white

mp

238-241 °C

solubility

water: soluble

application(s)

pharmaceutical

format

neat

shipped in

ambient

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

InChI key

JCBIVZZPXRZKTI-UHFFFAOYSA-N

Gene Information

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This Item
1327000PHR1782BP1101
vibrant-m

BP1100

Hydroxychloroquine sulfate

vibrant-m

1327000

Hydroxychloroquine sulfate

vibrant-m

PHR1782

Hydroxychloroquine Sulfate

format

neat

format

neat

format

-

format

neat

manufacturer/tradename

BP

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

BP

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

form

solid

form

-

form

powder or crystals

form

solid

agency

BP

agency

USP

agency

BP, EP, USP, traceable to BP 1100, traceable to USP 1327000

agency

BP

General description

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydroxychloroquine Sulfate can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.

Biochem/physiol Actions

Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

Packaging

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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British Pharmacopeia
British Pharmacopoeia, 44(12), 1000-1004 (2020)
Seminars in Arthritis and Rheumatism, 43(2), 264-272 (2013)
Compatibility study of hydroxychloroquine sulfate with pharmaceutical excipients using thermal and nonthermal techniques for the development of hard capsules
Moraes ANF, et al.
Journal of Thermal Analysis and Calorimetry, 421 (2019)
Pharmacokinetics and bioequivalence study of hydroxychloroquine sulfate tablets in Chinese healthy volunteers by LC--MS/MS
Fan HW, et al.
Rheumatology and therapy, 2(2) (2015)
Analytical interference of quinolone antibiotics and quinine derived drugs on urinary protein determined by reagent strips and the pyrogallol red-molybdate protein assay
da Silva AS and Falkenberg M
Clinical Biochemistry, 44(12) (2011)

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