Skip to Content
MilliporeSigma
  • Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease.

Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease.

Neurochemical research (2003-07-02)
S Engelborghs, B Marescau, P P De Deyn
ABSTRACT

To study changes in amino acid metabolism and biogenic amines in Parkinson's disease, we set up a prospective study and measured biogenic amines, their main metabolites, and 22 different amino acids, in cerebrospinal fluid of Parkinson's disease patients (n = 24) and age-matched controls (n = 30). A trend toward higher dopamine levels in Parkinson's disease patients was interpreted as an effect of treatment with levodopa and/or selegiline. Significantly lower concentrations of the dopamine metabolite 3,4-dihydroxyphenylacetic acid in the Parkinson's disease group might reflect dopaminergic cell loss. Our results revealed decreased serotonin catabolism that was interpreted as an effect of treatment with selegiline. Whereas all amino acid levels were unchanged, taurine was significantly lower in Parkinson's disease patients. Studies showed that taurine exerts a trophic action on the central nervous system. In this view, decreased taurine in a neurodegenerative disorder as Parkinson's disease deserves attention.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Aluminum, ReagentPlus®, beads, 5-15 mm, 99.9% trace metals basis
Sigma-Aldrich
Aluminum, ACS reagent, 99%, wire, wire diam. ~1.5 mm
Sigma-Aldrich
Mercury, ACS reagent, 99.9995% trace metals basis
Sigma-Aldrich
Glycine, SAJ special grade, ≥99.0%
Sigma-Aldrich
Mercury, JIS special grade, ≥99.5%
Sigma-Aldrich
Mercury, SAJ first grade, ≥99.5%
Sigma-Aldrich
Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%
Sigma-Aldrich
Nickel, nanopowder, <100 nm avg. part. size, ≥99% trace metals basis
Supelco
L-Cystine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Supelco
L-Tyrosine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Supelco
L-Aspartic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Supelco
L-Tyrosine, Pharmaceutical Secondary Standard; Certified Reference Material
Adrenaline, European Pharmacopoeia (EP) Reference Standard
Adrenaline with impurity F, European Pharmacopoeia (EP) Reference Standard
Cystine, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Aluminum, powder, <5 μm particle size, 99.5% trace metals basis
Sigma-Aldrich
Aluminum, foil, thickness 8 μm, 99% trace metals basis
Sigma-Aldrich
Magnesium, wire, 127 μm diameter, 99.9% trace metals basis
Sigma-Aldrich
L-Lysine, crystallized, ≥98.0% (NT)
Titanium, IRMM®, certified reference material, 0.5 mm wire
Sigma-Aldrich
Glycine, BioUltra, for molecular biology, ≥99.0% (NT)
Sigma-Aldrich
Zinc, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.9%, granular
Aluminum, IRMM®, certified reference material, 1.0 mm foil
Sigma-Aldrich
L-Aspartic acid, BioXtra, ≥99% (HPLC)
Sigma-Aldrich
Glycine, suitable for electrophoresis, ≥99%
Sigma-Aldrich
Glycine, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
L-Tyrosine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 99.0-101.0%
Sigma-Aldrich
Glycine, BioXtra, ≥99% (titration)
Sigma-Aldrich
L-Aspartic acid, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-Cystine, ≥98% (TLC), crystalline