377112

3-ピロリン

95%

• 別名: 2,5-ジヒドロピロール
• 実験式（ヒル表記法）: C₄H₇N
• CAS番号: 109-96-6
• 分子量: 69.11
• Beilstein: 103173
• EC Number: 203-723-1
• MDL番号: MFCD00005213
• UNSPSCコード: 12352100
• PubChem Substance ID: 24863493
• NACRES: NA.22

特性

• 品質水準: 100
• アッセイ: 95%
• 形状: liquid
• 屈折率: n20/D 1.46 (lit.)
• bp: 90-91 °C/748 mmHg (lit.)
• 密度: 0.91 g/mL at 25 °C (lit.)
• 保管温度: −20°C
• SMILES記法: C1NCC=C1
• InChI: 1S/C4H7N/c1-2-4-5-3-1/h1-2,5H,3-4H2
• InChI Key: JVQIKJMSUIMUDI-UHFFFAOYSA-N

詳細

詳細

3-Pyrroline is a heterocyclic building block. The excited state dynamics of 3-pyrroline by Hamiltonian model based on the vibronic coupling model has been investigated. Trifluoromethylated azomethine ylide is reported as precursor for the synthesis of 3-pyrroline building blocks. 3-Pyrrolines are reported as highly useful intermediates for the synthesis of functionalized pyrrolines, pyrrolidines and other natural products. Preparation of 3-pyrroline(2,5-dihydro-1H-pyrrole) from (Z)-1,4-dichloro-2-butene, via Delépine Reaction has been reported. It is formed as intermediate in the synthesis of N-(tert-butyloxycarbonyl)-3-pyrroline. Reaction of Me₃Al and Me₃Ga with 3-pyrroline is reported.

Various 3-pyrrolines (2,5-dihydropyrroles) have been synthesized by two-step reaction sequence of alkylation/alkylidene carbene CH-insertion reaction. Synthesis of 3-pyrroline has been reported by employing cis-1,4-dichloro-2-butene as starting reagent.

アプリケーション

レニン阻害剤や血管拡張剤の合成に用いられています。

安全性情報

• ピクトグラム: GHS02,GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H225,H302 + H332,H314
• 注意書き: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Flam. Liq. 2 - Skin Corr. 1A
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): -0.4 °F - closed cup
• 引火点(℃): -18 °C - closed cup
• 個人用保護具 (PPE): Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter