930237

2,5-dioxopyrrolidin-1-yl (2,5-dichlorobenzoyl)glycyl-L-leucinate

≥95%

• 別名: CANDDY_MLN Tag NHS ester
• 実験式（ヒル表記法）: C₁₉H₂₁Cl₂N₃O₆
• 分子量: 458.29
• UNSPSCコード: 12352209
• NACRES: NA.21

特性

• 品質水準: 100
• アッセイ: ≥95%
• フォーム: powder
• 保管温度: 2-8°C
• SMILES記法: ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1
• InChI: 1S/C19H21Cl2N3O6/c1-10(2)7-14(19(29)30-24-16(26)5-6-17(24)27)23-15(25)9-22-18(28)12-8-11(20)3-4-13(12)21/h3-4,8,10,14H,5-7,9H2,1-2H3,(H,22,28)(H,23,25)/t14-/m0/s1

詳細

アプリケーション

CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.

CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable