A-083

Amiodarone-D₄ hydrochloride solution

100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• 実験式（ヒル表記法）: C₂₅D₄H₂₆ClI₂NO₃
• CAS番号: 1216715-80-8
• 分子量: 685.80
• EC Number: 200-659-6
• MDL番号: MFCD08064189
• UNSPSCコード: 41116107
• PubChem Substance ID: 329770634
• NACRES: NA.24

特性

• グレード: certified reference material
• 品質水準: 300
• 形状: liquid
• 特徴: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• 濃度: 100 μg/mL in methanol (as free base)
• テクニック: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• アプリケーション: clinical testing
• フォーマット: single component solution
• 保管温度: −20°C
• SMILES記法: Cl.[2H]C([2H])(Oc1c(I)cc(cc1I)C(=O)c2c(CCCC)oc3ccccc23)C([2H])([2H])N(CC)CC
• InChI: 1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H/i13D2,14D2;
• InChI Key: ITPDYQOUSLNIHG-MMJSDMDPSA-N

詳細

詳細

A Certified Spiking Solution^®and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone^®, Cordarone^®, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range.

アプリケーション

• UV-Triggered Drug Release from Nanoparticles: Research explores the enhanced antibacterial activity of berberine hydrochloride-loaded mesoporous titanium nanoparticles, activated by UV exposure, providing insights into novel drug delivery systems for antiarrhythmic drugs like Amiodarone-D₄ hydrochloride in medical treatments (Zuo et al., 2024).


• Antioxidant Activity and Eczema Treatment: A study evaluates the antioxidant properties and therapeutic effects of berberine hydrochloride-loaded liposomes in gel form, potentially analogous to applications for encapsulated forms of Amiodarone-D₄ in dermal pharmaceutical preparations (Shen et al., 2024).


• Synthetic Routes for Cancer Therapy: A review on the synthetic pathways and clinical applications of small-molecule EGFR inhibitors for cancer treatment provides a framework that can be applied to the development and application of Amiodarone-D₄ hydrochloride in oncological research (Wang et al., 2024).


• Drug Release Behaviors in Nanoparticles: Investigation into the impact of various factors on the properties of poly(lactic-co-glycolic acid) nanoparticles co-loaded with hydrophilic and hydrophobic drugs, relevant for the formulation of Amiodarone-D₄ hydrochloride for controlled drug delivery systems (Wang et al., 2024).


• Traditional Chinese Medicine and Sjögren Syndrome: Case report on a rare pattern of primary Sjögren syndrome treated with traditional Chinese medicine, highlighting the diverse therapeutic approaches that could integrate Amiodarone-D₄ hydrochloride in complex treatment regimens (Chen et al., 2024).

法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Cordarone is a registered trademark of Sanofi S.A.

Pacerone is a registered trademark of Upsher-Smith Laboratories, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225,H301 + H311 + H331,H370
• 注意書き: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• ターゲットの組織: Eyes
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 1
• 引火点(°F): 49.5 °F - closed cup
• 引火点(℃): 9.7 °C - closed cup