360512

Glycocholic Acid, Sodium Salt

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

• 別名: Glycocholic Acid, Sodium Salt, GAS, Sodium cholylglycinate
• CAS番号: 863-57-0
• MDL番号: MFCD00669624
• UNSPSCコード: 12352106
• NACRES: NA.21

特性

• 品質水準: 100
• アッセイ: 100.1% dry basis (titration)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 凝集数: 2.1
• 色: white to off-white
• pKa: 3.8
• CMC: 7.1 mM
• 溶解性: water: 200 mg/mL; ethanol: soluble
• 輸送温度: ambient
• 保管温度: 15-25°C
• SMILES記法: [Na+].N(CC(=O)[O-])C(=O)CCC(C1C2(C(C3C(C4(C(CC3O)CC(CC4)O)C)CC2O)CC1)C)C
• InChI: 1S/C26H43NO6.Na/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);/q;+1/p-1
• InChI Key: OABYVIYXWMZFFJ-UHFFFAOYSA-M

詳細

詳細

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

Glycocholic acid (GCA) is a crystalline secondary bile acid. It is a conjugate of cholic acid and glycine. The microbiota produces GCA in the small intestine by the catalysis of enzymes. Glycocholic Acid, Sodium Salt, an anionic surfactant with a steroidal backbone is soluble in water.Formed by the conjugation of cholic acid with glycine (aggregation number: 2.1; CMC: 7.1 mM; pK_a: 3.8).

アプリケーション

Glycocholic Acid, Sodium Salt- is suitable for use:

• as a component in the sodium phosphate/NaCl (phosphate buffer saline-PBS) buffer to prepare protein samples
• in the preparation of fluorescently labeled mixed micelles to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations of vitamin K
• to prepare mixed micelle solutions to encapsulate a lipid-soluble drug (vitamin K₁) to analyze its influence on the quality and stability of the mixed micelle systems

生物化学的／生理学的作用

Glycocholic acid (GCA) is involved in the emulsification of fats. Glycocholic acid sodium (GAS) salt is one of the important cholic acid salts in the pharmaceutical industry used to prepare mixed micelles (MMs).

警告

Toxicity: Standard Handling (A)

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable