AB5580
Anti-SCN8A Sodium Channel Antibody
Chemicon®, from rabbit
別名:
Sodium Channel Nav1.6, NaCh6, PN4, CerIII
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About This Item
UNSPSCコード:
12352203
eCl@ss:
32160702
NACRES:
NA.41
クローン:
polyclonal
application:
ICC
IHC
WB
IHC
WB
化学種の反応性:
rat, mouse
テクニック:
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
citations:
10
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由来生物
rabbit
品質水準
抗体製品の状態
affinity purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
polyclonal
精製方法
affinity chromatography
化学種の反応性
rat, mouse
メーカー／製品名
Chemicon®
テクニック
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... SCN8A(6334)
詳細
Voltage-gated sodium channels perform critical roles for electrical signaling in the nervous ssystem by generating action potentials in axons and dndrites. At least 10 genes encode sodium channels in mammals, but specific physiological roles that distinguish each of these isoforms are not well known. Nav1.6 is highly concentrated at notes of Ranvier of both sensory and motor axons in the peripheral nervous system and at nodes in the central nervous system. Because of its consistant and restrictied labeling, Anti-Nav1.6 (AB5580) has been used effectively as a nodes of Ranvier marker.
特異性
Recognizes Scn8a (Nav1.6). The epitope corresponds to the intracellular loop between II and III domains of Scn8a. Does not cross react with any other known proteins.
SPECIES REACTIVITIES: It is expected that the antibody will also work on mouse (20/20) and human (19/20) due to sequence homology. Other species have not been tested.
SPECIES REACTIVITIES: It is expected that the antibody will also work on mouse (20/20) and human (19/20) due to sequence homology. Other species have not been tested.
免疫原
Peptide corresponding to amino acids 1042-1061 from mouse (Accession number AAD20438) or rat (Accession number AAC26014) Scn8a.
アプリケーション
Detect SCN8A Sodium Channel using this Anti-SCN8A Sodium Channel Antibody validated for use in IC, IH & WB.
Western blot: (1:200) using ECL on rat brain membranes.
Immunohistochemistry on fixed frozen sections.
Immunocytochemistry on rat dorsal root ganglion primary culture (1:100)
Dilutions should be made using a carrier protein such as BSA (1-3%)
Optimal working dilutions must be determined by the end user.
Immunohistochemistry on fixed frozen sections.
Immunocytochemistry on rat dorsal root ganglion primary culture (1:100)
Dilutions should be made using a carrier protein such as BSA (1-3%)
Optimal working dilutions must be determined by the end user.
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
毒物及び劇物取締法
毒物
Jan Code
AB5580-50UL:
AB5580-200UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Jacy L Wagnon et al.
Neurology. Genetics, 3(4), e170-e170 (2017-07-14)
To determine the functional effect of SCN8A missense mutations in 2 children with intellectual disability and developmental delay but no seizures. Genomic DNA was analyzed by next-generation sequencing. SCN8A variants were introduced into the Nav1.6 complementary DNA by site-directed mutagenesis.
Ping Li et al.
eNeuro, 4(3) (2017-07-01)
The GABA-B receptor is densely expressed throughout the brain and has been implicated in many CNS functions and disorders, including addiction, epilepsy, spasticity, schizophrenia, anxiety, cognitive deficits, and depression, as well as various aspects of nervous system development. How one
Devid Damiani et al.
The Journal of comparative neurology, 520(7), 1406-1423 (2011-11-22)
Retinitis pigmentosa (RP) is a family of inherited diseases causing progressive photoreceptor death. Retinal ganglion cells (RGCs) form the biological substrate for various therapeutic approaches designed to restore vision in RP individuals. Assessment of survival and preservation of RGCs in
Yasmina Manso et al.
Glia, 66(1), 34-46 (2017-07-20)
Chronic cerebral hypoperfusion is a key mechanism associated with white matter disruption in cerebral vascular disease and dementia. In a mouse model relevant to studying cerebral vascular disease, we have previously shown that cerebral hypoperfusion disrupts axon-glial integrity and the
Michell M Reimer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(49), 18185-18194 (2011-12-14)
Myelinated axons have a distinct protein architecture essential for action potential propagation, neuronal communication, and maintaining cognitive function. Damage to myelinated axons, associated with cerebral hypoperfusion, contributes to age-related cognitive decline. We sought to determine early alterations in the protein
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