59349

アンピシリン

analytical standard

• 別名: D-(−)-α-アミノベンジルペニシリン
• 実験式（ヒル表記法）: C₁₆H₁₉N₃O₄S
• CAS番号: 69-53-4
• 分子量: 349.40
• Beilstein: 1090925
• EC Number: 200-709-7
• MDL番号: MFCD00005175
• UNSPSCコード: 41116107
• PubChem Substance ID: 329758626
• NACRES: NA.24

特性

• グレード: analytical standard
• 品質水準: 100
• アッセイ: ≥95.0% anhydrous basis (NT)
• シェルフライフ: limited shelf life, expiry date on the label
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• 不純物: ≤20% water
• mp: 208 °C (dec.) (lit.)
• アプリケーション: clinical testing
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: [H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](N)c3ccccc3)C(O)=O
• InChI: 1S/C16H19N3O4S/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23)/t9-,10-,11+,14-/m1/s1
• InChI Key: AVKUERGKIZMTKX-NJBDSQKTSA-N

詳細

詳細

Chemical structure: β-lactam
Ampicillin belongs to the β-lactum group of antibiotics. It is used to treat bacterial infections via penetrating gram positive and gram negative bacteria. Its mode of action basically involves the inhibition of bacterial cell wall synthesis, thus leading to cell lysis.

アプリケーション

Ampicillin has been used as a reference compound in the determination of ampicillin free drug concentration in standard solution of human serum albumin by micellar liquid chromatography method.

Ampicillin is a semi-synthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It has been used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生物化学的／生理学的作用

作用機序：半合成のペニシリンであるアンピリシンは、細菌の細胞膜の内面でトランスペプチダーゼを失活させることによって細菌の細胞壁の合成を阻害するβ-ラクタムです。

耐性機序：β-ラクタマーゼを投与するとアンピシリンのラクタム環が開裂し、それを失活させます。

抗菌スペクトル：グラム陽性細菌（ベンジルペニシリンと同様）およびグラム陰性細菌（テトラサイクリンおよびクロラムフェニコールと同様）の両方に対して有効です。

包装

This product is packaged in a bottomless glass bottle with the contents inside an inserted fused cone.

注意

This product has been reported stable as supplied at 25°C at 43% and 81% relative humidity for six weeks. Additional studies have shown that the stability of Ampicillin in solution is a function of pH, temperature and the identity of the buffer. It′s activity is quickly lost when stored above pH 7. Optimal storage conditions are suggested as 2-8°C, and pH 3.8-5 where its activity was retained at 90%+ for a week.

調製ノート

Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H317,H334
• 注意書き: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• 危険有害性の分類: Resp. Sens. 1 - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable