A2612

アシアチン酸

≥98% (HPLC), from Centella asiatica

• 別名: 2α,23-ジヒドロキシウルソール酸, NSC 166063, ダンマロール酸
• 実験式（ヒル表記法）: C₃₀H₄₈O₅
• CAS番号: 464-92-6
• 分子量: 488.70
• EC Number: 482-720-9
• MDL番号: MFCD00238541
• UNSPSCコード: 12352212
• PubChem Substance ID: 329770790
• NACRES: NA.25

特性

• 由来生物: Centella asiatica
• 品質水準: 200
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: protect from light
• 色: white
• mp: 325-330 °C (lit.)
• 溶解性: methanol: 1 mg/mL, clear, colorless
• アプリケーション: metabolomics; vitamins, nutraceuticals, and natural products
• 保管温度: 2-8°C
• SMILES記法: C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
• InChI: 1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1
• InChI Key: JXSVIVRDWWRQRT-UYDOISQJSA-N

詳細

詳細

Asiatic acid is a naturally occurring pentacyclic triterpenoid, obtained from Centella asiatica.

アプリケーション

以下の用途で使用されるアジア酸誘導体合成の出発物質です。

• 抗癌剤
• グリコーゲンホスホリラーゼ阻害剤
• 肝臓保護剤

Asiatic acid has been used in the in vitro study of its cytotoxic potential in glioblastoma cells. It has also been used for the in vivo quantitative analysis of asiatic acid in Centella asiatica L. and in vitro study of enhancement of asiatic acid yield upon using organic elicitors.

生物化学的／生理学的作用

Asiatic acid has been reported to exhibit a pernicious effect on glioblastoma, breast, liver, melanoma, and colon cancers and anti-angiogenic activity. Additionally, it can cross the blood-brain barrier and cause apoptosis in human malignant glioma and hepatoma cells. Asiatic acid also effectively inhibits the Ultraviolet A modulated signal transduction pathways and thereby can be used against UVA-induced photoaging of the skin. It has been noted to show antinociceptive and anti-inflammatory properties plus inhibitory effect on neurotoxicity induced by β-amyloid and glutamate.

アジア酸は、創傷治癒で広く使用されています。アジア酸には、抗酸化性、抗炎症性、および神経保護作用があります。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable