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About This Item
実験式（ヒル表記法）:
C26H24N4O2 · HCl
CAS番号:
分子量:
460.96
MDL番号:
UNSPSCコード:
12352111
PubChem Substance ID:
NACRES:
NA.77
おすすめの製品
由来生物
synthetic (organic)
品質水準
アッセイ
≥90%
フォーム
solid
溶解性
DMSO: soluble
保管温度
−20°C
SMILES記法
Cl.Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16
InChI
1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H
InChI Key
IMBOYWXMTUUYGZ-UHFFFAOYSA-N
アプリケーション
Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor:
- in chemotaxis assays
- to inhibit protein kinase C and to study its effects on the expression of EGR1, NAB2, ZEBRA, and Rta
- in the culture to study its effects on the expression of the kinase-insert domain-containing receptor (KDR)-B1, protein kinase Cθ (PKCθ)-M1a or Abl-HTa and on cell yield in baculovirus (BV)-infected insect cells
生物化学的／生理学的作用
Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKC in vitro with an IC50 of 5nM.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
B3931-VAR:
B3931-BULK:
B3931-5MG:
B3931-1MG:
B3931-1MG-PW:
B3931-5MG-PW:
最新バージョンのいずれかを選択してください：
Markus Ackerknecht et al.
Frontiers in immunology, 6, 297-297 (2015-06-25)
Intravital imaging has revealed that T cells change their migratory behavior during physiological activation inside lymphoid tissue. Yet, it remains less well investigated how the intrinsic migratory capacity of activated T cells is regulated by chemokine receptor levels or other
Jianjiang Ye et al.
Journal of virology, 84(23), 12405-12418 (2010-09-24)
The Epstein-Barr virus (EBV) lytic activator genes bzlf1 and brlf1 are conventionally referred to as immediate-early (IE) genes. However, previous studies showed that the earliest expression of these genes was blocked by cycloheximide when the EBV lytic cycle was induced
André Strauss et al.
Protein expression and purification, 56(2), 167-176 (2007-08-28)
As exemplified by three cases, we show that the addition of a small molecular weight inhibitor to the culture of Baculovirus-infected insect cells can dramatically improve the expression of a recombinant kinase. The expression of the tyrosine kinase KDR was
J E Merritt et al.
Cellular signalling, 9(1), 53-57 (1997-01-01)
Previous studies implicating a role for protein kinase C (PKC) in mediating stimulation of cellular responses by physiological agonists have relied on use of non-specific inhibitors or direct stimulation of PKC by phorbol esters. However, much of this evidence is
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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