K1136

ケトロラック トリス塩

≥99%, crystalline

• 別名: (±)-5-ベンゾイル-2,3-ジヒドロ-1H-ピロリジン-1-カルボン酸 トリス塩, トラドール
• 実験式（ヒル表記法）: C₁₅H₁₃NO₃ · C₄H₁₁NO₃
• CAS番号: 74103-07-4
• 分子量: 376.40
• MDL番号: MFCD00887595
• UNSPSCコード: 12352202
• PubChem Substance ID: 24278503
• NACRES: NA.77

特性

• 由来生物: synthetic (organic)
• 品質水準: 100
• アッセイ: ≥99%
• 形状: crystalline
• 溶解性: H₂O: soluble 15 mg/mL, clear, colorless to faintly yellow (stable at least one month at −20 °C.)
• 保管温度: room temp
• SMILES記法: NC(CO)(CO)CO.OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3
• InChI: 1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
• InChI Key: BWHLPLXXIDYSNW-UHFFFAOYSA-N
• 遺伝子情報: human ... PTGS1(5742) , PTGS2(5743)

詳細

アプリケーション

Ketorolac has been used:

• as an intraperitoneal injection in mice to study the effect of ketorolac on expression of c-Fos (a human proto-oncogene) in ARC (arcuate nucleus of the hypothalamus) POMC (proopiomelanocortin) -EGFP (enhanced green fluorescent protein) neurons
• to treat mice in order to show that this treatment does not prevent IL-1β-mediated inhibition of Agouti-related protein (AgRP) secretion from murine hypothalamic explants
• as an analgesic medication to treat rats induced with acute inflammatory joint injury by injecting carrageenan into the ankle

生物化学的／生理学的作用

Ketorolac is a non-steroidal agent that possesses moderate anti-inflammatory activity and is also a potent analgesic. It shows superior analgesic efficacy to that of the opioid analgesics like morphine in patients with moderate to severe postsurgical pain. It inhibits prostaglandin synthesis and platelet aggregation induced by arachidonic acid and collagen. It is a dual COX-1/COX-2 inhibitor.

注意

室温で保存した場合、2年間以上にわたって安定です。

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H319,H335
• 注意書き: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges