M0319

MRS 2578

≥95% (HPLC)

• 別名: 1,4-ジ[3-(3-イソチオシアナートフェニル)チオウレイド]ブタン
• 実験式（ヒル表記法）: C₂₀H₂₀N₆S₄
• CAS番号: 711019-86-2
• 分子量: 472.67
• MDL番号: MFCD07370141
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724530
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white
• 溶解性: DMSO: >5 mg/mL; H₂O: insoluble
• 保管温度: 2-8°C
• SMILES記法: S=C=Nc1cccc(NC(=S)NCCCCNC(=S)Nc2cccc(c2)N=C=S)c1
• InChI: 1S/C20H20N6S4/c27-13-23-15-5-3-7-17(11-15)25-19(29)21-9-1-2-10-22-20(30)26-18-8-4-6-16(12-18)24-14-28/h3-8,11-12H,1-2,9-10H2,(H2,21,25,29)(H2,22,26,30)
• InChI Key: QOHNRGHTJPFMSL-UHFFFAOYSA-N

詳細

アプリケーション

MRS 2578 has been used an antagonist of purinoceptor P2Y6:

• to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
• in P. aeruginosa infected mice to test its effect on the inflammatory responses
• to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes

生物化学的／生理学的作用

MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.

P2Y₆ ヌクレオチドレセプタ-に対する強力な不可逆的アンタゴニストです。

特徴および利点

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H312 + H332,H315,H319,H334,H335
• 注意書き: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves