O7760

オカダ酸 ナトリウム塩 渦鞭毛藻Prorocentrum concavum由来

≥90% (HPLC), film

• 別名: OA
• 実験式（ヒル表記法）: C₄₄H₆₇NaO₁₃
• CAS番号: 209266-80-8
• 分子量: 826.98
• MDL番号: MFCD00210208
• UNSPSCコード: 12352106
• PubChem Substance ID: 329818921
• NACRES: NA.77

特性

• 由来生物: plant (Prorocentrum concavum)
• 品質水準: 200
• アッセイ: ≥90% (HPLC)
• 形状: film
• 色: translucent
• 溶解性: 0.1% acetic acid in CH₃CN: H₂O (1:1): 250 μg/mL, clear, colorless
• 保管温度: −20°C
• SMILES記法: [Na+].C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@H](O)[C@H]3O[C@@H]4CC[C@@]5(CC[C@@H](O5)\C=C\[C@@H](C)[C@@H]6CC(C)=C[C@@]7(O[C@@H](CC[C@H]7O)C[C@@](C)(O)C([O-])=O)O6)O[C@H]4[C@H](O)C3=C
• InChI: 1S/C44H68O13.Na/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42;/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49);/q;+1/p-1/b10-9+;/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-;/m1./s1
• InChI Key: BYHIFOCTDVNQQT-GHIYGBLASA-M

詳細

生物化学的／生理学的作用

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

特徴および利点

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301 + H311 + H331,H315
• 注意書き: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3