P6749

モノクロナール抗p53 マウス宿主抗体

clone PAb1801, purified from hybridoma cell culture

• 別名: 抗TRP53抗体, 抗形質転換関連タンパク質53抗体
• MDL番号: MFCD00164709
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: PAb1801, monoclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~53 kDa
• 化学種の反応性: human
• 濃度: ~2 mg/mL
• テクニック: immunohistochemistry: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; western blot: 0.03-0.06 μg/mL using total cell extract of A431 cells
• アイソタイプ: IgG1
• UniProtアクセッション番号: P04637
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TP53(7157)

詳細

詳細

Anti-p53 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma PAb1801 produced by the fusion of mouse myeloma cells (SP2 cells) and splenocytes from BALB/c mice immunized with recombinant human wild type p53. Anti-p53 antibody, Mouse monoclonal recognizes human p53.
p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

アプリケーション

Monoclonal Anti-p53-Biotin antibody produced in mouse has been used for Western Blotting.

生物化学的／生理学的作用

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

物理的形状

0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)