SAB4502012

Anti-INOS antibody produced in rabbit

affinity isolated antibody

• 別名: INDUCIBLE, MACROPHAGE, NITRIC OXIDE SYNTHASE, NOS2A
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 131 kDa
• 化学種の反応性: human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:20000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBIアクセッション番号: P35228
• UniProtアクセッション番号: P35228
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... NOS2(4843)

詳細

詳細

Anti-INOS antibody detects endogenous levels of total INOS protein.

The INOS (inducible nitric oxide synthase) gene is mapped to human chromosome 17q11.2.

免疫原

The antiserum was produced against synthesized peptide derived from human iNOS.

Immunogen Range: 1101-1150

アプリケーション

Anti-INOS, C-Terminal antibody produced in rabbit has been used in immunoblotting.

生物化学的／生理学的作用

Upregulation of INOS (inducible nitric oxide synthase) is observed during infections, tissue injury, and inflammation. INOS is responsible to produce NO (nitric oxide), which controls blood flow by inducing vascular relaxation. NO acts as a neurotransmitter and can facilitate immune responses. NO can also bring about anti-thrombotic and anti-inflammatory effects in response to oxidative stress, hypoxia, inflammatory cytokines (TNF-α, IL-1β, IFN-γ), and lipopolysaccharide endotoxin. iNOS generates more NO than the neuronal and endothelial NOS. Unlike the two isoforms, iNOS is calcium independent. INOS might be associated with type 2 diabetes mellitus.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable