SAB4700262

Monoclonal Anti-CD105 antibody produced in mouse

clone MEM-229, purified immunoglobulin, buffered aqueous solution

• 別名: 抗CD105抗体, 抗ENG抗体, 抗エンドグリン抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: MEM-229, monoclonal
• 形状: buffered aqueous solution
• 化学種の反応性: human, pig
• 濃度: 1 mg/mL
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG2a
• NCBIアクセッション番号: NM_000118.2
• UniProtアクセッション番号: P17813
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ENG(2022)

詳細

詳細

CD105, also known as endoglin (ENG) gene is mapped to human chromosome 9q34.11. The gene codes for a homodimeric transmembrane coreceptor containing disulfide-linked subunits of 95kDa. The encoded protein is mainly expressed on human pre-erythroblasts, macrophages, leukemic cells of the lymphoid and myeloid lineages. It is also present at higher levels on syncytiotrophoblasts of term placenta and vascular endothelial cells.

The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

免疫原

Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA

アプリケーション

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Flow cytometry/Cell sorting (1 paper)

生物化学的／生理学的作用

CD105/ endoglin (ENG) acts as an accessory receptor within transforming growth factor (TGF)-β signalling pathway. It is implicated in the regulation of TGF-β-dependent cellular responses. The protein expressed in endothelial cells plays a vital role in angiogenesis and tumour progression. CD105 functions as a potential target of epigenetic silencing in lung cancer. Deletion of the gene leads to hereditary hemorrhagic telangiectasia. In addition, mutations in the gene is also associated with various cardiovascular anomalies and different types of cancers.

特徴および利点

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物理的形状

PBS（pH 7.4、15 mM アジ化ナトリウム含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable