SML3123

NButGT

≥98% (HPLC)

• 別名: (3aR,5R,6S,7R,7aR)-3a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-propyl-5H-pyrano[3,2-d]thiazole-6,7-diol
• 実験式（ヒル表記法）: C₁₀H₁₇NO₄S
• CAS番号: 863918-55-2
• 分子量: 247.31
• UNSPSCコード: 41106609
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: -10 to -25°C
• SMILES記法: CCCC1=N[C@@H]2[C@H]([C@@H]([C@H](O[C@@H]2S1)CO)O)O

詳細

生物化学的／生理学的作用

NButGT is a potent and selective inhibitor of O-GlcNAcase (OGA), which elevates O-GlcNAc levels but does not cause insulin resistance in 3T3-L1 adipocytes, and in rats and mice. NButGT does not perturbed glucohomeostasis when used for extended time in rats and mice. NButGT attenuates the accumulation of Aβ, neuroinflammation, and memory in in a mouse model of Alzheimer’s disease. NButGT efficiently increased total O-GlcNAc, improves cardiovascular function and reduced animal mortality in rat model of sepsis.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable