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由来生物
Streptomyces tubercidicus
品質水準
アッセイ
~95%
フォーム
powder
色
off-white
抗生物質活性スペクトル
fungi
parasites
viruses
作用機序
DNA synthesis | interferes
SMILES記法
O[C@H]1[C@@H](O)[C@H](N2C=CC3=C2N=CN=C3N)O[C@@H]1CO
InChI
1S/C11H14N4O4/c12-9-5-1-2-15(10(5)14-4-13-9)11-8(18)7(17)6(3-16)19-11/h1-2,4,6-8,11,16-18H,3H2,(H2,12,13,14)/t6-,7-,8-,11-/m1/s1
InChI Key
HDZZVAMISRMYHH-KCGFPETGSA-N
遺伝子情報
rat ... Adora1(29290)
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詳細
Chemical structure: nucleoside
アプリケーション
It is used to study tubercidin′s mechanism of toxicity, tubercidin resistance and is used as a selection agent. Tubercidin is used to study RNAi silencing. It is used to study the role of transmethylation in chemotaxis of eukaryotic cells.
生物化学的／生理学的作用
Tubercidin is a toxic adenosine analog with antiviral, antitrypanosomal, and antifungal functions. It inhibits multiple metabolic processes, including RNA processing, nucleic acid synthesis, protein synthesis, and methylation of tRNA through intracellular incorporation into nucleic acids. Tubercidin acts as a plant antifungal, inhibits mammalian SAH hydrolase (SAHH), and blocks purine biosynthesis in Candida famata. Tubercidin inhibits glycolysis in Trypanosoma brucei. Tubercidin inhibits both chemotaxis and chemotaxis-dependent cell streaming of Dictyostelium, and chemotaxis of neutrophils at concentrations that have little effect on cell viability.
抗ウイルス性、抗トリパノソーマ性、抗真菌性を有する毒性のアデノシンアナログです。 作用の様態:核酸の細胞内取り込みにより、RNAプロセシング、核酸合成、タンパク質合成、tRNAメチル化など、様々な代謝プロセスを阻害します。植物用抗真菌剤として作用するツベルシジンは、哺乳類のSAH加水分解酵素(SAHH)を阻害し、Candida famataのプリン生合成を阻害します。
その他情報
Keep container tightly closed in a dry and well-ventilated place.
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 2 Oral
保管分類コード
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T0642-10MG:
T0642-VAR:
T0642-50MG:
T0642-100MG:
T0642-BULK:
T0642-250MG:
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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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