T4680

テラゾシン 塩酸塩

≥98% (TLC), powder

• 別名: 1-(4-アミノ-6,7-ジメトキシ-2-キナゾリニル)-4-[(テトラヒドロ-2-フラニル)カルボニル]ピペラジン 塩酸塩
• 実験式（ヒル表記法）: C₁₉H₂₅N₅O₄ · HCl
• CAS番号: 63074-08-8
• 分子量: 423.89
• MDL番号: MFCD00467965
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278740
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥98% (TLC)
• 形状: powder
• 色: white to off-white
• 溶解性: H₂O: soluble 19.60-20.40 mg/mL, clear, colorless to faintly yellow; methanol: 20 mg/mL, clear, colorless; ethanol: 4 mg/mL
• オーガナイザー: Abbott
• SMILES記法: Cl[H].COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4
• InChI: 1S/C19H25N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H
• InChI Key: IWSWDOUXSCRCKW-UHFFFAOYSA-N
• 遺伝子情報: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

詳細

詳細

Terazosin hydrochloride is used to treat hypertension and benign prostatic hyperplasia (BPH). It is metabolised in the liver. It might be associated with dizziness, headache and asthenia. Terazosin hydrochloride is linked to acute generalized exanthematous pustulosis.

アプリケーション

Terazosin hydrochloride has been used for orthogonality and similarity analysis using reversed-phase chromatographic studies⁵. Furthermore, terazosin has also been used for the evaluation of chemometric techniques to determine orthogonality and similarity in chromatographic methods⁶.

生物化学的／生理学的作用

α₁-アドレナリンレセプタ-アンタゴニストです。

特徴および利点

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

調製ノート

Terazosin hydrochloride is soluble in water at 19.60 - 20.40 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol at 4 mg/ml. Furthermore, the product is soluble in methanol at 20 mg/ml, with heat as needed, and yields a clear, colorless solution.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves