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About This Item
実験式（ヒル表記法）:
C10H10N2O2S
CAS番号:
分子量:
222.26
MDL番号:
UNSPSCコード:
12352200
PubChem Substance ID:
NACRES:
NA.77
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品質水準
アッセイ
≥98% (HPLC)
フォーム
needles
保管条件
protect from light
色
white
mp
63-64.4 °C
溶解性
DMSO: >10 mg/mL
保管温度
2-8°C
SMILES記法
CN1SC(=O)N(Cc2ccccc2)C1=O
InChI
1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
InChI Key
JDSJDASOXWCHPN-UHFFFAOYSA-N
アプリケーション
TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.
生物化学的／生理学的作用
GSK-3の選択的インヒビタ-であり、チアジアゾリジノン誘導体です。GSK-3βの非ATP競合阻害剤です(IC50 = 2 μM)。濃度100 μM以上でCdk-1/サイクリンB, CK-II, PKA, PKCに対する阻害はありません。GSK-3βのキナ-ゼ部位に結合するといわれています。
TDZD-8 is a selective inhibitor of GSK-3.
特徴および利点
This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
調製ノート
TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T8325-5MG:
T8325-VAR:
T8325-25MG:
T8325-BULK:
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