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品質水準
アッセイ
≥98% (HPLC)
形状
powder
色
white
溶解性
DMSO: >10 mg/mL
H2O: insoluble
保管温度
2-8°C
SMILES記法
[O-][N+](=O)c1ccc(Cl)c(c1)C(=O)Nc2ccncc2
InChI
1S/C12H8ClN3O3/c13-11-2-1-9(16(18)19)7-10(11)12(17)15-8-3-5-14-6-4-8/h1-7H,(H,14,15,17)
InChI Key
FRPJSHKMZHWJBE-UHFFFAOYSA-N
詳細
T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.
アプリケーション
T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.
T0070907 or Benzamide has been used as a ADP-ribosyltransferase (ADPRT) inhibitor in rat hippocampal slices. It has also been used for urine analysis in patients diagnosed with acute uncomplicated urinary tract infection.
生物化学的／生理学的作用
T0070907は構造と活性がPPAR-γアンタゴニストGW9662にきわめて類似しています。T0070907は、他のどのサブタイプよりもPPAR-γに対して強力に作用し、高い選択性を示しますが(約800倍)、GW9662はPPAR-αアゴニスト活性を示すことが報告されています。
特徴および利点
This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
調製ノート
T0070907 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
保管分類コード
11 - Combustible Solids
WGK
WGK 2
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T8703-IP:
T8703-VAR:
T8703-BULK:
T8703-5MG:
T8703-25MG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Wogonin attenuates inflammation by activating PPAR-gamma in alcoholic liver disease
Li HD, et al.
International Immunopharmacology, 50, 95-106 (2017)
T0070907, a PPAR gamma inhibitor, induced G2/M arrest enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe
An Z, et al.
Reproductive Sciences, 21(11), 1352-1361 (2014)
E M Schuman et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(25), 11958-11962 (1994-12-06)
Recent studies of long-term potentiation (LTP) in the CA1 region of the hippocampus have demonstrated that nitric oxide (NO) may be involved in some forms of LTP and have suggested that postsynaptically generated NO is a candidate to act as
Changsung Kim et al.
Nature, 494(7435), 105-110 (2013-01-29)
Cellular reprogramming of somatic cells to patient-specific induced pluripotent stem cells (iPSCs) enables in vitro modelling of human genetic disorders for pathogenic investigations and therapeutic screens. However, using iPSC-derived cardiomyocytes (iPSC-CMs) to model an adult-onset heart disease remains challenging owing
Sreedevi Avasarala et al.
Biology open, 2(7), 675-685 (2013-07-19)
In non-small cell lung cancer cell lines, activation of β-catenin independent signaling, via Wnt7a/Frizzled9 signaling, leads to reversal of cellular transformation, reduced anchorage-independent growth and induction of epithelial differentiation. miRNA expression profiling on a human lung adenocarcinoma cell line (A549)
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