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Ag(I)-catalyzed aminofluorination of alkynes: efficient synthesis of 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.

Ag(I)-catalyzed aminofluorination of alkynes: efficient synthesis of 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.

Organic letters (2012-10-24)

Tao Xu, Guosheng Liu

要旨

A silver-catalyzed intramolecular oxidative aminofluorination of alkynes has been developed by using NFSI as a fluorinating reagent. This reaction represents an efficient method for the synthesis of various 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.

材料

製品番号

ブランド

製品内容

Sigma-Aldrich

硝酸銀, ACS reagent, ≥99.0%

Sigma-Aldrich

硝酸銀, ReagentPlus^®, ≥99.0% (titration)

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硝酸銀, 99.9999% trace metals basis

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硝酸銀, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8%

Sigma-Aldrich

硝酸銀, JIS special grade, ≥99.8%

Sigma-Aldrich

硝酸銀, meets analytical specification of Ph. Eur., BP, USP, 99.8-100.5%

Sigma-Aldrich

硝酸銀, puriss. p.a., ≥99.5% (AT)

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硝酸銀溶液, 2.5 % (w/v) AgNO₃ in H₂O

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硝酸銀, BioReagent, suitable for plant cell culture, >99% (titration)

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シリカゲル硝酸銀, extent of labeling: ~10 wt. % loading, +230 mesh

Sigma-Aldrich

硝酸銀溶液, 0.1 M

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硝酸銀溶液, 0.01 M

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硝酸銀, SAJ first grade, ≥99.8%

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硝酸銀溶液, 0.02 M

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硝酸銀, BioXtra, >99% (titration)

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硝酸銀溶液, 0.0282 M

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硝酸銀溶液, 0.05 M

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Silver standard solution, suitable for atomic absorption spectrometry, 1 mg/mL Ag, 1000 ppm Ag

Sigma-Aldrich

硝酸銀, tested according to Ph. Eur.