M0639

6α-Methylprednisolone

≥98%

• 동의어(들): 11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, Medrol, Medrone
• 실험식(Hill 표기법): C₂₂H₃₀O₅
• CAS Number: 83-43-2
• Molecular Weight: 374.47
• Beilstein: 2340300
• EC Number: 201-476-4
• MDL number: MFCD00010591
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24896564
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 무균: non-sterile
• 분석: ≥98%
• 형태: powder
• solubility: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
• 응용 분야: cell analysis
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: [H][C@@]12C[C@H](C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
• InChI key: VHRSUDSXCMQTMA-PJHHCJLFSA-N
• 유전자 정보: human ... NR3C1(2908) ; rat ... Nr3c1(24413)

설명

애플리케이션

6α-Methylprednisolone has been used:

• to stimulate RPMI 8226.1 cells in order to govern the expression of human interleukin-10 (IL-10) gene
• to induce depletion of CD14⁺ CD16⁺ monocytes
• to study its effect on behavioral and sensory afferent hypersensitivity

생화학적/생리학적 작용

Methylprednisolone is a glucocorticoid having anti-inflammatory and immunosuppressive actions. It is useful in treating skin diseases, allergies, multiple sclerosis, asthma, rheumatic disorders, chronic obstructive pulmonary disease, croup and cancer.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360FD,H373
• 예방조치 성명서: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B - STOT RE 2
• 표적 기관: Adrenal gland,Immune system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)