M6316

MRS 1754 hydrate

≥98% (HPLC), solid

• 동의어(들): 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
• 실험식(Hill 표기법): C₂₆H₂₆N₆O₄ · xH₂O
• CAS Number: 264622-58-4
• Molecular Weight: 486.52 (anhydrous basis)
• MDL number: MFCD11046004
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278793
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: off-white
• solubility: DMSO: soluble >10 mg/mL
• 저장 온도: room temp
• SMILES string: O.CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)-c3ccc(OCC(=O)Nc4ccc(cc4)C#N)cc3
• InChI: 1S/C26H26N6O4.H2O/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19;/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30);1H2
• InChI key: ZACJDWOPQROWIK-UHFFFAOYSA-N
• 유전자 정보: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) ; rat ... Adora1(29290) , Adora2a(25369) , Adora2b(29316)

설명

애플리케이션

MRS 1754 hydrate has been used as an adenosine receptor A2B (RA2B) antagonist:

• to study its effects on endothelial nitric oxide synthase (eNOS) phosphorylation induced by short-term acetate stimulation in human umbilical vein endothelial cells (HUVECs)
• blastema formation in zebrafish
• to serve as a positive control in the anti-sickling assay and to study the role of RA2B in the same

생화학적/생리학적 작용

MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.

MRS 1754 hydrate is a potent A_2B adenosine receptor antagonist.

특징 및 장점

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

법적 정보

Manufactured and sold under license from Adenosine Therapeutics LLC.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)