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Merck
모든 사진(1)

주요 문서

Q3625

Sigma-Aldrich

Quinidine

sodium channel blocker

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About This Item

실험식(Hill 표기법):
C20H24N2O2
CAS Number:
Molecular Weight:
324.42
Beilstein:
91866
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

제품명

Quinidine, anhydrous

Grade

anhydrous

Quality Level

불순물

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

mp

168-172 °C (lit.)

주관자

Bayer

SMILES string

COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1

InChI

1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1

InChI key

LOUPRKONTZGTKE-LHHVKLHASA-N

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애플리케이션

Quinidine has been used:
  • as an inhibitor of cytochrome P450 enzyme isoform CYP2D6
  • as a potassium (K+) channel blocker in microglia
  • to test its effect on electrophysiological behaviour of human induced pluripotent stem cells (hiPSC) cardiomyocytes

생화학적/생리학적 작용

Class IA antiarrhythmic; potassium channel blocker.
Quinidine, an isomer of quinine has potential side effects like proarrhythmia on usage. It prolongs cardiac potential and is sodium channel blocker. It is a potential antagonist for α1-adrenoceptors and contributes to hypotension. It inhibits cytochrome P450 2D6 and improves circulation and brain penetration of dementia drug, dextromethorphan. Quinidine-dextromethorphan combination may be useful in treating pseudobulbar affect (PBA).

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Skull and crossbones

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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문서 라이브러리 방문

이미 열람한 고객

Danny Jans et al.
Journal of pharmacological and toxicological methods, 87, 48-52 (2017-05-28)
Drug-induced cardiotoxicity poses a negative impact on public health and drug development. Cardiac safety pharmacology issues urged for the preclinical assessment of drug-induced ventricular arrhythmia leading to the design of several in vitro electrophysiological screening assays. In general, patch clamp
Yang Zheng et al.
The Journal of pharmacology and experimental therapeutics (2022-12-03)
The cardiac sodium channel Nav1.5 is a key contributor to the cardiac action potential and dysregulations in Nav1.5 can lead to cardiac arrhythmias. Nav1.5 is a target of numerous antiarrhythmic drugs (AADs). Previous studies identified the protein 14-3-3 as a
Pharmacological treatments for alleviating agitation in dementia: a systematic review and network meta-analysis
Kongpakwattana K, et al.
British Journal of Clinical Pharmacology, 84(7), 1445-1456 (2018)
Dextromethorphan/quinidine: a review of its use in adults with pseudobulbar affect
Yang LPH and Deeks ED
Drugs, 75(1), 83-90 (2015)
Cardiac Sodium Channel Disorders An Issue of Cardiac Electrophysiology Clinics E-Book, 6(4) (2015)

문서

Discover Bioactive Small Molecules for ADME/Tox

프로토콜

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

관련 콘텐츠

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