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Merck
모든 사진(3)

주요 문서

S9132

Sigma-Aldrich

Spiramycin

동의어(들):

Rovamycin, Formacidine

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC 코드:
51283208
PubChem Substance ID:
NACRES:
NA.85

형태

powder

Quality Level

광학 활성

[α]/D -85 to -80° in water (Specific rotation (dry basis))

효능

≥4100 I.U. per mg (dry basis)

저장 조건

(Keep container tightly closed in a dry and well-ventilated place.)

색상

white to light yellow

solubility

methanol: soluble

양이온 미량물

heavy metals: ≤20 ppm

항생제 활성 스펙트럼

Gram-positive bacteria

동작 모드

protein synthesis | interferes

저장 온도

2-8°C

SMILES string

CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](OC2CCC(C(C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1OC3OC(C)C(OC4CC(C)(O)C(O)C(C)O4)C(C3O)N(C)C

InChI

1S/C43H74N2O14/c1-24-21-29(19-20-46)39(59-42-37(49)36(45(9)10)38(27(4)56-42)58-35-23-43(6,51)41(50)28(5)55-35)40(52-11)31(47)22-33(48)53-25(2)15-13-12-14-16-32(24)57-34-18-17-30(44(7)8)26(3)54-34/h12-14,16,20,24-32,34-42,47,49-51H,15,17-19,21-23H2,1-11H3/b13-12+,16-14+/t24-,25-,26?,27?,28?,29+,30?,31-,32+,34?,35?,36?,37?,38?,39+,40+,41?,42?,43?/m1/s1

InChI key

ACTOXUHEUCPTEW-JMRHEKERSA-N

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일반 설명

Chemical structure: macrolide

애플리케이션

Spiramycin is a macrolide antibiotic that is commonly used to treat infections of soft tissues. It has been used to treat bronchopulmonary infections in adults and has been used to study septicemia in mice .

생화학적/생리학적 작용

Spiramycin is a 16-membered ring macrolide antibiotic from Streptomyces ambofaciens. It inhibits bacterial protein synthesis at the level of peptidy-tRNA dissociation from ribosomes. It is mainly used against Gram-positive bacteria.

품질

A mixture of Spiramycin I, II and III.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

Yonca Acikgoz et al.
Pediatric transplantation, 16(4), E115-E119 (2011-02-16)
Cryptosporidium is an intracellular protozoan parasite that causes gastroenteritis in human. In immunocompromised individuals, cryptosporidium causes far more serious disease. There is no effective specific therapy for cryptosporidiosis, and spontaneous recovery is the rule in healthy individuals. However, immunocompromised patients
Severe congenital toxoplasmosis due to a Toxoplasma gondii strain with an atypical genotype: case report and review.
Laurence Delhaes et al.
Prenatal diagnosis, 30(9), 902-905 (2010-06-29)
I Brook
Clinical pharmacokinetics, 34(4), 303-310 (1998-05-08)
The absolute bioavailability of oral spiramycin is generally within the range of 30 to 40%. After a 1 g oral dose, the maximum serum drug concentration was found to be within the range 0.4 to 1.4 mg/L. The tissue distribution
Ming-juan Wang et al.
Journal of chromatography. A, 1217(42), 6531-6544 (2010-09-17)
Investigation of acetylspiramycin (ASPM) and its related substances was carried out using a reversed-phase liquid chromatography/tandem mass spectrometry method. The identification of impurities in the ASPM complex was performed with a quadrupole ion trap mass spectrometer, with an electrospray ionization
Ying Liu et al.
Ecotoxicology and environmental safety, 86, 23-30 (2012-09-29)
Cyanobacteria may interact with antibiotic contaminants in aquatic environments, but the interaction effects and mechanisms remain unclear. In the present study, aqueous culture of Microcystis aeruginosa was exposed to 50ng/l-1μg/l of spiramycin and amoxicillin for seven days. The influences of

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