SML0632

Fialuridine

≥98% (HPLC), powder, nucleoside analog

• 동의어(들): 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-Pyrimidinedione, FIAU
• 실험식(Hill 표기법): C₉H₁₀FIN₂O₅
• CAS Number: 69123-98-4
• Molecular Weight: 372.09
• MDL number: MFCD00866922
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825571
• NACRES: NA.77

속성

• 제품명: Fialuridine, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• 저장 온도: −20°C
• SMILES string: F[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C(NC(C(I)=C2)=O)=O
• InChI: 1S/C9H10FIN2O5/c10-5-6(15)4(2-14)18-8(5)13-1-3(11)7(16)12-9(13)17/h1,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5+,6-,8-/m1/s1
• InChI key: IPVFGAYTKQKGBM-BYPJNBLXSA-N

설명

일반 설명

Fialuridine (1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-iodouracil, or FIAU) is an antiviral agent. It is a thymidine-based nucleoside analogue.

애플리케이션

Fialuridine has been used in the selection of clones.

생화학적/생리학적 작용

Fialuridine (1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)-5-iodouracil, or FIAU) and its metabolites blocks DNA polymerase at sites of multiple adjacent analog incorporation, reduces the presence of mtDNA (mitochondrial DNA) and results in mitochondrial structural defects in cultured hepatoblasts. It is considered as an efficient drug against hepatitis B virus (HBV) infection.

Fialuridine is a nucleoside analog antiviral agent.

Fialuridine is a nucleoside analog antiviral agent. The compound displays significant mitochondrial toxicity.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable