MilliporeSigma
All Photos(1)

Documents

805092

Sigma-Aldrich

PLGA nanoparticles

100 nm average diameter

Sign Into View Organizational & Contract Pricing

Select a Size

Synonym(s):
Degradex® PLGA, poly(D,L-lactide-co-glycolide)
Linear Formula:
HO(C3H4O2)x(C2H2O2)yH

form

powder

Quality Level

average diameter

100 nm

density

1.3 g/cm3

shipped in

wet ice

storage temp.

−20°C

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
805149805122805300
PLGA nanoparticles 100 nm average diameter

Sigma-Aldrich

805092

PLGA nanoparticles

Sigma-Aldrich

Sigma-Aldrich

805149

PLGA nanoparticles

PLGA microspheres 50 μm average diameter

Sigma-Aldrich

805122

PLGA microspheres

average diameter

100 nm

average diameter

500 nm

average diameter

50 μm

average diameter

500 nm

density

1.3 g/cm3

density

1.3 g/cm3

density

1.3 g/cm3

density

1.3 g/cm3

shipped in

wet ice

shipped in

wet ice

shipped in

-

shipped in

wet ice

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

General description

Degradex® is made with poly(D,L-lactide-co-glycolide) with an L/G ratio of 50/50 and a Mw of 30,000.
To re-constitute:
  • Remove the product from freezer.
  • Wait until temperature rises to the ambient temperature.
  • Add DI water or buffer to the container.
  • Vortex and sonicate for 5 minutes to ensure the microspheres are well suspended.
The particle size of the PLGA nanoparticles are closely dependent on both the nature and concentration of the stabilizer and polymer.

Application

Plain PLGA particles can be used for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PLGA particles are used for controlled release, sustained release and targeted drug delivery.A study reports the use of PLGA nanoparticles as estrogen carriers. The carrier-drug system was prepared by emulsification-diffusion method.

Legal Information

Degradex is a registered trademark of Phosphorex, Inc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method
Kwon HY, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 182(1-3), 123-130 (2001)
The Characteristics and Mechanisms of Uptake of PLGA Nanoparticles in Rabbit Conjunctival Epithelial Cell Layers
Qaddoumi MG, et al.
Pharmaceut. Res., 21(4), 641-648 null

Articles

Degradex® Microspheres and Nanoparticles for Drug Delivery Research and Formulation Development

Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.

Polymeric Antioxidants and Nanobiomaterials for Innovative Therapeutic Modalities

Polymeric antioxidants are promising and effective new-generation antioxidant therapies. With flexibility of form as well as prolonged stability and circulation, these nanobiomaterials have superior bioavailability for drug delivery and antioxidant potential.

Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

Biomaterials science involves the design and fabrication of smart materials for studying, directing, or mimicking biology. For successful integration of biomaterials in biological research, a meaningful understanding of biological systems is required.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service