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Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 80:20

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Synonym(s):
PEG-PLGA, PEG2K-PLGA10K, mPEG-b-PLGA
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3

form

powder or chunks

feed ratio

lactide:glycolide 80:20

mol wt

PEG average Mn 2,000 (by NMR)
PLGA average Mn 10,000 (by NMR)

color

off-white to faint brown

storage temp.

−20°C

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This Item
911429913138900921
storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

mol wt

PEG average Mn 2,000 (by NMR), PLGA average Mn 10,000 (by NMR)

mol wt

PEG average Mn 5,000 (by NMR), PLGA average Mn 5,000 (by NMR)

mol wt

PEG average Mn 2,000, PLGA average Mn 10,000 (by NMR)

mol wt

PEG average Mn 2,000, PLGA Mn 3,000

feed ratio

lactide:glycolide 80:20

feed ratio

lactide:glycolide 80:20

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 50:50

color

off-white to faint brown

color

white

color

white to beige

color

-

Application

This polymer is a amphiphilic diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. This biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these
Fabienne Danhier et al.
Journal of controlled release : official journal of the Controlled Release Society, 133(1), 11-17 (2008-10-28)
The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor EL. PTX-loaded PEGylated
Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their

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