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C80105

Sigma-Aldrich

Chrysin

97%

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Synonym(s):
5,7-Dihydroxyflavone
Empirical Formula (Hill Notation):
C15H10O4
CAS Number:
Molecular Weight:
254.24
Beilstein/REAXYS Number:
233276
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

assay

97%

form

powder

mp

284-286 °C (lit.)

solubility

0.1 M NaOH: 0.008 g/L

λmax

348 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccccc3

InChI

1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H

InChI key

RTIXKCRFFJGDFG-UHFFFAOYSA-N

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1 of 4

This Item
O750522680247367
Chrysin 97%

C80105

Chrysin

Orcein synthetic, certified by the Biological Stain Commission

O7505

Orcein

Quinoline Yellow for microscopy (Hist.), mixture of mono- and disulfonic acid sodium salt

22680

Quinoline Yellow

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

form

powder

form

powder

form

powder

form

crystalline powder

λmax

348 nm

λmax

-

λmax

-

λmax

415 nm

assay

97%

assay

-

assay

-

assay

≥99%

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

Application

  • Chrysin has been used to study the effect of bioflavonoids on the inhibition of ATP synthase in Escherichia coli.
  • It has been used to study the effect of Chrysin on eIF4E (eukaryotic translation initiation factor 4E) expression in AGS cell (human gastric carcinoma cell) line.
  • It has been used to study the effect of chrysin on human ovarian cancer cells.

Biochem/physiol Actions

Chrysin is a flavonoid and an analog of apigenin. It inhibits aromatase and also suppresses human immunodeficiency virus (HIV) activation in models with latent infection. Chrysin exhibits anti-inflammatory and anti-oxidant effects. This molecule induces apoptosis in various cells, thereby exhibiting cancer chemopreventive activity. Chrysin can modulate the activity of GABAA (Type-A γ-aminobutyric acid) and GABAC receptors, it downregulates expression of PCNA (proliferating cell nuclear antigen), reduces activity of CDK2 (cyclin-dependent kinase 2) and CDK4 and induces p38-MAPK (mitogen-activated protein kinase) activation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Cytotoxic and Pro-Apoptotic Effects of Honey Bee Venom and Chrysin on Human Ovarian Cancer Cells.
Amini E, et al.
Asia Pacific Journal of Medical Toxicology, 4 (2015)
H J Jeong et al.
Archives of pharmacal research, 22(3), 309-312 (1999-07-14)
In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest
Apoptotic effects of chrysin in human cancer cell lines.
Khoo BY, et al.
International Journal of Molecular Sciences, 11, 2188-2188 (2010)
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase.
Weng MS, et al.
Biochemical Pharmacology, 69, 1815-1815 (2005)
Evaluation of the effect of Chrysin and Caffeic acid phenethyl ester on eIF4E expression in AGS cell line.
Abolhasani M, et al.
Journal of HerbMed Pharmacology, 3 (2014)

Articles

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