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M4008

Sigma-Aldrich

Morin hydrate

powder

Synonym(s):

2′,3,4′,5,7-Pentahydroxyflavone

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About This Item

Empirical Formula (Hill Notation):
C15H10O7 · xH2O
CAS Number:
654055-01-3
Molecular Weight:
302.24 (anhydrous basis)
EC Number:
207-542-9
MDL number:
MFCD00217054
UNSPSC Code:
12171500
PubChem Substance ID:
24278552
NACRES:
NA.77

form

powder

color

yellow

solubility

methanol: 50 mg/mL

SMILES string

O.Oc1ccc(c(O)c1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2

InChI

1S/C15H10O7.H2O/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15;/h1-5,16-19,21H;1H2

InChI key

MYUBTSPIIFYCIU-UHFFFAOYSA-N

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Application

Morin hydrate has been used:
  • to investigate its antitumor functionality using cell viability and apoptosis assay in human cancer cell lines.
  • as a fluorescence stain to detect aluminum in motor neurons and lumbar cord.
  • to study its protective effect on neuronal hearing loss and on neural stem cells (NSCs) proliferation and differentiation

Biochem/physiol Actions

Morin hydrate is a flavonoid with antioxidant properties. It has been shown to protect cells against oxygen radical damage. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase, a free-radical generating enzyme. At concentrations of 75-100 micromolar, morin inhibits oxidation of low density lipoprotein (LDL) by free radicals or Cu2+. Morin has been reported to inhibit rat brain phospha­tidyl­inositol­phos­phate kinase activity in vitro and in vivo.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Christopher A Shaw et al.
Journal of inorganic biochemistry, 103(11), 1555-1562 (2009-09-11)
Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990-1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable
T W Wu et al.
Biochemical pharmacology, 49(4), 537-543 (1995-02-14)
Morin hydrate is a bioactive pigment found in yellow Brazil wood. Recently, we reported that morin hydrate prolongs the survival of three types of cells from the human circulatory system against oxyradicals generated in vitro. The protection excels that given
T W Wu et al.
Life sciences, 58(2), PL 17-PL 22 (1996-01-01)
We demonstrated that the flavonoid morin hydrate at 75-100 microM protects against the oxidation of low density lipoprotein (LDL) by free radicals produced by 2,2'-azo-bis(2-amidinopropane) dihydrochloride. Morin hydrate reduces the relative electrophoretic mobility, malondialdehyde equivalents and lipid peroxide level of
T W Wu et al.
Life sciences, 57(3), PL51-PL56 (1995-01-01)
Oxidative modification of low density lipoprotein (LDL) has been suggested to be a risk factor for the development of atherosclerosis. Agents which can protect LDL from oxidation may be useful in preventing atherogenesis. Here, we found that morin hydrate, at
L H Zeng et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 75(6), 717-720 (1997-01-01)
Oxygen-derived free radicals are known to injure the endothelium of aorta in diverse disorders. In this study we compared the cytoprotective effects of three flavonoids against oxyradical damage to porcine aortic endothelial cells in vitro. Cultured porcine aortic endothelial cells
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Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

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