341274-M

Factor H, Human

Factor H, Human, is a single-chain multi-functional glycoprotein that regulates formation and function of complement C3 and C5 convertase enzymes.

• Synonym(s): β _1H Globulin, β_1H Globulin
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (SDS-PAGE)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles
• impurities: IgG, IgA, IgM, Factor I, Factor B, Factor P, C3, C4, or albumin, trace (Ouchterlony)
• storage temp.: −70°C

Description

General description

Native factor H from human serum. Single-chain glycoprotein present in normal human serum at about 500 µg/ml. Regulates formation and function of complement C3 and C5 convertase enzymes. A C3b-binding protein, not an enzyme. Regulatory activity is attributed to its ability to recognize and bind to C3b fragments.

Native factor H from human serum. Single-chain multi-functional glycoprotein present in normal human serum at about 500 µg/ml. Regulates formation and function of complement C3 and C5 convertase enzymes. A C3b-binding protein that does not exhibit enzymatic activity. Regulatory activity is attributed to its ability to recognize and bind to C3b fragments.

Warning

Toxicity: Standard Handling (A)

Physical form

In PBS, pH 7.2.

Preparation Note

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Zipfel, P.F., et al. 1999. Immunopharmacology 42, 53.
Pangburn, M.K. and Muller-Eberhard, H.J. 1984. Springer Semin. Immunopathol. 7, 163.
Fearon, D.T. and Austen, K.F. 1977. Proc. Natl. Acad. Sci. USA 74, 1683.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable