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MAB1293

Sigma-Aldrich

Anti-DNA Antibody, double stranded, clone AE-2

clone AE-2, Chemicon®, from mouse

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eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

AE-2, monoclonal

species reactivity (predicted by homology)

all

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable

isotype

IgG3

shipped in

wet ice

target post-translational modification

unmodified

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MAB1950MAB3562MAB3404
biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

clone

AE-2, monoclonal

clone

P1E6, monoclonal

clone

2-2, monoclonal

clone

CK2, monoclonal

manufacturer/tradename

Chemicon®

manufacturer/tradename

Chemicon®

manufacturer/tradename

Chemicon®

manufacturer/tradename

Chemicon®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable

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Specificity

Double stranded DNA. MAB1293 produces a homogeneous staining pattern in the nucleus of normal and malignant cells.

Immunogen

Epitope: double stranded
Nuclei of Raji Burkitt′s lymphoma cells

Application

Anti-DNA Antibody, double stranded, clone AE-2 is a high quality Mouse Monoclonal Antibody for the detection of DNA & has been validated in ICC & IHC.
Immunocytochemistry: paraformaldehyde fixed cell preparations

Immunohistochemistry: paraformaldehyde fixed frozen tissue sections

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected double stranded DNA in human prostrate and tonsil tissue sections.

Optimal working dilutions must be determined by the end user.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair

Physical form

Format: Purified
Purified immunoglobulin. Liquid in 0.02M Phosphate buffer with 0.25 NaCl and 0.1% sodium azide.

Storage and Stability

Maintain at 2-8°C in undiluted aliquots for up to 6 months.

Analysis Note

Control
POSITIVE CONTROL: Human tonsil

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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1000309185

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Manuel Adrian Suter et al.
Scientific reports, 11(1), 7243-7243 (2021-04-02)
Deficiencies in DNA repair and DNA degrading nucleases lead to accumulation of cytosolic DNA. cGAS is a critical DNA sensor for the detection of cytosolic DNA and subsequent activation of the STING signaling pathway. Here, we show that the cGAS-STING
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Sangita Khatri et al.
Journal of translational autoimmunity, 3, 100068-100068 (2020-11-19)
Neuropsychiatric systemic lupus erythematosus is an autoimmune disorder characterized by an irregular exchange between the central nervous system and the immune system, leading to the outbreak of neurological conditions with possible disabling effects. Although neuropsychiatric systemic lupus erythematosus is the
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(45), 9286-9307 (2021-10-02)
Adult-onset neurodegenerative diseases are often accompanied by evidence of a chronic inflammation that includes activation of microglial cells and altered levels of brain cytokines. Aspects of this response are likely secondary reactions to neurodegeneration, but for many illnesses the inflammation

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