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34854

Sigma-Aldrich

Chloroform

suitable for HPLC, ≥99.8%, amylene stabilized

Synonym(s):

Methylidyne trichloride, Trichloromethane

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About This Item

Empirical Formula (Hill Notation):
CHCl3
CAS Number:
67-66-3
Molecular Weight:
119.38
Beilstein/REAXYS Number:
1731042
EC Number:
200-663-8
MDL number:
MFCD00000826
UNSPSC Code:
41116105
PubChem Substance ID:
329755063
NACRES:
NA.04

vapor density

4.1 (vs air)

Quality Level

100

vapor pressure

160 mmHg ( 20 °C)

assay

≥99.8%

form

liquid

quality

amylene stabilized

technique(s)

HPLC: suitable

impurities

Free acid, in accordance
 acetone, aldehyde, in accordance (nessler test)
 free chlorine (Cl), in accordance
≤0.0005% non-volatile matter
≤0.001% free acid (as HCl)
<0.01% water (Karl Fischer)

evapn. residue

≤0.0005%

color

APHA: ≤10

transmittance

250 nm, ≥50%
260 nm, ≥85%
280 nm, ≥99%

refractive index

n20/D 1.445 (lit.)

bp

60.5-61.5 °C (lit.)

mp

−63 °C (lit.)

density

1.48 g/mL at 25 °C
1.492 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): in accordance

cation traces

Pb: ≤0.05 mg/kg

absorption

in accordance

λ

H2O reference

UV absorption

λ: 250 nm Amax: ≤1.00
λ: 260 nm Amax: ≤0.30
λ: 280 nm Amax: ≤0.005

suitability

passes test for reaction against H2SO4
passes test for suitability of determ. w. dithizone

application(s)

food and beverages

SMILES string

ClC(Cl)Cl

InChI

1S/CHCl3/c2-1(3)4/h1H

InChI key

HEDRZPFGACZZDS-UHFFFAOYSA-N

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General description

Chloroform, a halogenated hydrocarbon, is widely employed as a solvent. Its photochemical degradation has been investigated in the presence of TiO2 aqueous suspensions (wavelength range of 310-380nm).

Application

Chloroform has been employed for the ion exchange isolation of sulfatides from the urinary samples by using DEAE-cellulose membranes before the tandem mass spectrometric analysis. It has been used as a solvent for the Langmuir-Blodgett (LB) deposition of lipid bilayers over mica sheets (silver coated back).†

Other Notes

Important notice
  • The article number 34854-4X2.5L will be discontinued. Please order the single bottle 34854-2.5L which is physically identical with the same exact specifications.

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Certificates of Analysis (COA)

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Ladislav Kuchař et al.
Clinica chimica acta; international journal of clinical chemistry, 425, 153-159 (2013-07-11)
Prediagnostic steps in suspected metachromatic leukodystrophy (MLD) rely on clinical chemical methods other than enzyme assays. We report a new diagnostic method which evaluates changes in the spectrum of molecular types of sulfatides (3-O-sulfogalactosyl ceramides) in MLD urine. The procedure
Photolysis of chloroform and other organic molecules in aqueous titanium dioxide suspensions.
Kormann C, et al.
Environmental Science & Technology, 25(3), 494-500 (1991)
Kuan Sun et al.
Nature communications, 6, 6013-6013 (2015-01-15)
Solution-processed organic photovoltaic cells (OPVs) hold great promise to enable roll-to-roll printing of environmentally friendly, mechanically flexible and cost-effective photovoltaic devices. Nevertheless, many high-performing systems show best power conversion efficiencies (PCEs) with a thin active layer (thickness is ~100 nm) that
Shuiquan Tang et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 368(1616), 20120318-20120318 (2013-03-13)
Two novel reductive dehalogenases (RDases) that are highly similar to each other but catalyse distinct dechlorination reactions were identified from Dehalobacter-containing mixed cultures. These two RDases were partially purified from crude protein extracts of anaerobic dechlorinating enrichment cultures using blue
Radovan Spurny et al.
The Journal of biological chemistry, 288(12), 8355-8364 (2013-02-01)
Pentameric ligand-gated ion channels (pLGICs), such as nicotinic acetylcholine, glycine, γ-aminobutyric acid GABA(A/C) receptors, and the Gloeobacter violaceus ligand-gated ion channel (GLIC), are receptors that contain multiple allosteric binding sites for a variety of therapeutics, including general anesthetics. Here, we
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