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Sigma-Aldrich

FITC-CM-Dextran

average mol wt 70,000

Synonym(s):

FITC-CM-Dextran 70, Fluorescein isothiocyanate–Carboxymethyl–Dextran

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About This Item

UNSPSC Code:
12352116
NACRES:
NA.32

conjugate

FITC conjugate

Quality Level

100

form

powder or crystals

mol wt

average mol wt 70,000

composition

carboxymethyl content, 3-7%

extent of labeling

0.001-0.020 mol/mol FITC glucose

technique(s)

permeability assay: suitable

fluorescence

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

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General description

FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform. FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.

Application

FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge. It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS. FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Harada M, Murata J, Sakamura Y, et al.
J. Controlled Release, 71, 71-86 (2001)
Yogy Simanjuntak et al.
PLoS pathogens, 16(5), e1008521-e1008521 (2020-05-12)
Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregnancy, folic acid (FA) supplementation may reduce the risk of abnormal pregnancy outcomes. Intriguingly, FA may have a beneficial effect on
Giulia Paci et al.
eLife, 9 (2020-07-22)
Nucleocytoplasmic transport is tightly regulated by the nuclear pore complex (NPC). Among the thousands of molecules that cross the NPC, even very large (>15 nm) cargoes such as pathogens, mRNAs and pre-ribosomes can pass the NPC intact. For these cargoes
Chloe Martin et al.
International journal of pharmaceutics, 511(1), 570-578 (2016-07-28)
The need to develop a greater understanding of drug delivery systems has arisen through the development of alternative biological based therapeutics. Drug delivery systems need to adapt and respond to this increasing demand for cellular transportation of highly charged species.
Xing-Ding Zhang et al.
PloS one, 8(5), e63245-e63245 (2013-05-23)
We have previously reported that the mitochondria inhibitor 3-nitropropionic acid (3-NP), induces the expression of DNA damage-regulated autophagy modulator1 (DRAM1) and activation of autophagy in rat striatum. Although the role of DRAM1 in autophagy has been previously characterized, the detailed
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