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A6661

Sigma-Aldrich

Albumin, dinitrophenyl

lyophilized powder

Synonym(s):

DNP-albumin human

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25 G
$33.70
100 G
$91.00

About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.25

$33.70


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biological source

human

Quality Level

form

lyophilized powder

extent of labeling

30-40 mol DNP per mol albumin

UniProt accession no.

storage temp.

2-8°C

SMILES string

FC(F)(F)C(F)(F)C(F)(F)F

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

Gene Information

human ... ALB(213)

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This Item
PHR1125G639276523
storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

-

storage temp.

-

mp

185 °C (dec.) (lit.)

mp

185 °C (dec.) (lit.)

mp

185 °C (dec.) (lit.)

mp

185 °C (dec.) (lit.)

solubility

100 g/L

solubility

-

solubility

H2O: 10 mL/vial, clear to slightly hazy

solubility

-

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

300

potency

7500 mg/kg LD50, oral (Rat)

potency

-

potency

-

potency

-

Application

Albumin, dinitrophenyl has been used to assess degranulation from rat mast cells by treatment of:
  • bakkenolide B[1]
  • 4-Hydroxy-2-(4-hydroxyphenethyl)isoindoline-1,3-dione (PD1)[2]
  • mifepristone[3]
Used for detection in immunological analyses. Can be used as an immunological challenge to activate basophils via the IgE receptor.[4]

Analysis Note

Source material has tested negative for HIV and HBsAg

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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B Jabril-Cuenod et al.
The Journal of biological chemistry, 271(27), 16268-16272 (1996-07-05)
Antigen receptors on T- and B-cells activate Ras through a signaling pathway that results in the tyrosine phosphorylation of Shc and the formation of a complex of Shc with the Grb2 adaptor protein. The high affinity receptor for immunoglobulin E
Xuan Che et al.
International journal of medical sciences, 17(2), 224-233 (2020-02-11)
Background: Adenomyosis is a quite common gynecological disorder and above 30% of patients have typical secondary and progressive dysmenorrhea. Current treatments still have many disadvantages and thereby the novel treatment aiming to relieve dysmenorrhea still needs to be further investigated.
Little, S.R. and Eisen, H.N.
Methods Immunol. Immunochem., 1, 128-128 (1967)
Carolin N Zorn et al.
Scientific reports, 8(1), 15467-15467 (2018-10-21)
Antigen (Ag)-mediated crosslinking of IgE-loaded high-affinity receptors for IgE (FcεRI) on mast cells (MCs) triggers activation of proinflammatory effector functions relevant for IgE-associated allergic disorders. The cytosolic tyrosine kinase BTK and the SH2-containing inositol-5'-phosphatase SHIP1 are central positive and negative
G J Heywood et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 51(4), 176-181 (2002-06-13)
Nicorandil is a potassium channel opener and nitric oxide (NO) donor, and the hypothesis was tested that these modes of action may inhibit cellular degranulation and release of tumour necrosis factor-alpha (TNF-alpha). TNF-alpha and beta-hexosaminidase secretion were measured from rat

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