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FD70S

Sigma-Aldrich

Fluorescein isothiocyanate–dextran

average mol wt 60,000-76,000

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Synonym(s):
FITC–Dextran
CAS Number:
MDL number:
NACRES:
NA.25

biological source

bacterial (Leuconostoc mesenteroides)

Quality Level

conjugate

FITC conjugate

form

powder

mol wt

average mol wt 60,000-76,000

extent of labeling

0.003-0.020 mol FITC per mol glucose

color

yellow to yellow-orange

solubility

H2O: 25 mg/mL, clear to slightly hazy, yellow-orange

storage temp.

2-8°C

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This Item
FD250SFD40SFD150S
form

powder

form

powder

form

powder

form

powder

color

yellow to yellow-orange

color

yellow to orange

color

yellow to dark orange

color

faint yellow to orange

solubility

H2O: 25 mg/mL, clear to slightly hazy, yellow-orange

solubility

water: 25 mg/mL, clear, yellow

solubility

H2O: soluble 25 mg/mL, clear to slightly hazy, yellow to deep orange

solubility

H2O: 25 mg/mL, clear to slightly hazy, yellow-orange

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
FITC-dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination. Small FITC-dextrans are also used to measure processes such as endocytosis and cell junction permeability. FITC-dextran 70 kDa (FD-70) may be used as a model compound for development of methods to deliver molecules into protoplasts and to study drug release from structures such as hydrogels and liposomes. FD-70 may be used in microvascular and cell monolayer permeability studies.

Linkage

Similar to FD-70, but produced by Sigma.

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Michael J Shirey et al.
Journal of neurophysiology, 114(1), 309-322 (2015-05-15)
Changes in brain temperature can alter electrical properties of neurons and cause changes in behavior. However, it is not well understood how behaviors, like locomotion, or experimental manipulations, like anesthesia, alter brain temperature. We implanted thermocouples in sensorimotor cortex of
Gabriela Hurtado-Alvarado et al.
PloS one, 11(11), e0167236-e0167236 (2016-11-29)
Chronic sleep restriction induces blood-brain barrier disruption and increases pro-inflammatory mediators in rodents. Those inflammatory mediators may modulate the blood-brain barrier and constitute a link between sleep loss and blood-brain barrier physiology. We propose that adenosine action on its A2A
Maira Carrillo et al.
Medicine, 97(39), e12392-e12392 (2018-10-04)
Imaging of placental tissues is a difficult task, because of specific for this organ complex multicellular and 3D tissue structure. The tissue clearing systems (X-CLARITY) system is a valuable tool for the examining the expression of molecular pathways in whole
Isma Bennabi et al.
Nature communications, 11(1), 1649-1649 (2020-04-05)
Human and mouse oocytes' developmental potential can be predicted by their mechanical properties. Their development into blastocysts requires a specific stiffness window. In this study, we combine live-cell and computational imaging, laser ablation, and biophysical measurements to investigate how deregulation
Xue Dong et al.
Theranostics, 11(11), 5107-5126 (2021-04-17)
Background: Pathological angiogenesis is the hallmark of many vision-threatening diseases. Anti-VEGF is a primary treatment with substantial beneficial effects. However, such agents require frequent intravitreal injections. Our previous work established a method for effectively modifying exosomes (EXOs) for loading therapeutic

Related Content

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

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