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P9158

Sigma-Aldrich

Pyridoxamine dihydrochloride

BioReagent, suitable for cell culture

Synonym(s):

4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H12N2O2 · 2HCl
CAS Number:
524-36-7
Molecular Weight:
241.11
Beilstein/REAXYS Number:
3632748
EC Number:
208-357-6
MDL number:
MFCD00012808
UNSPSC Code:
12352205
PubChem Substance ID:
24899015
NACRES:
NA.75
Pricing and availability is not currently available.

biological source

synthetic (organic)

product line

BioReagent

assay

≥98%

form

powder

mol wt

Mw 241.11 g/mol

technique(s)

cell culture | mammalian: suitable

color

white to off-white

mp

224-226 °C (dec.) (lit.)

solubility

water: soluble 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

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Application

Use in mammalian cell culture as an alternative to pyridoxine or pyridoxal. Vitamin B6 is a required component of cell culture media. Historically, media have been supplemented with vitamin B6 in the aldehyde form, pyridoxal. While this is a biologically active form of vitamin B6, it is unstable in liquid media. When cells are able to utilize either pyridoxine and/or pyridoxamine, they are preferred supplement versus pyridoxal. A number of classical media are now offered with a choice between pyridoxal and pyridoxine as the vitamin A source.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000350129
0000350129
0000334060
0000334060
028K15381

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Ali Dehnad et al.
The Journal of clinical investigation, 130(8), 4320-4330 (2020-07-14)
Type 2 diabetes is clinically associated with progressive necroinflammation and fibrosis in nonalcoholic steatohepatitis (NASH). Advanced glycation end-products (AGEs) accumulate during prolonged hyperglycemia, but the mechanistic pathways that lead to accelerated liver fibrosis have not been well defined. In this
Petia Kovatcheva-Datchary et al.
Cell reports, 26(13), 3772-3783 (2019-03-28)
The gut microbiota can modulate human metabolism through interactions with macronutrients. However, microbiota-diet-host interactions are difficult to study because bacteria interact in complex food webs in concert with the host, and many of the bacteria are not yet characterized. To

Articles

Vitamin B6, Pyridoxal and Pyridoxine in Cell Culture

Vitamin B6's impact on serum-free cell culture systems is explored for protein manufacturing.

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