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species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
capture ELISA: suitable
input
sample type serum
sample type cell culture supernatant(s)
sample type plasma
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL10(3586)
Related Categories
General description
Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells and B cells. Murine IL-10 is inactive on human cells. The gene encoding this protein is localized on human chromosome 1q31-32.
Immunogen
Recombinant Human IL-10
Application
For research use only. Not for use in diagnostic procedures.
Human IL-10 ELISA kit has been used for determining the levels of IL-10 in cell culture supernatant.
Human IL-10 ELISA kit has been used for determining the levels of IL-10 in cell culture supernatant.
Human IL-10 ELISA Kit has been used in enzyme-linked immunosorbent assay (ELISA) to detect interleukin-10 (IL-10) in the plasma of uremic patients undergoing hemodialysis (HD).
Biochem/physiol Actions
IL-10 (interleukin 10) is an anti-inflammatory cytokine. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF (tumor necrosis factor)-α. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Polymorphisms in the IL-10 gene are associated with higher risk of preeclampsia, ankylosing spondylitis, nasopharyngeal carcinoma and basal cell carcinoma. Polymorphism in IL-10 at -1082A/G is associated with diabetic nephropathy.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit Components Also Available Separately
Product No.
Description
SDS
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
wgk_germany
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Identification of functional domains on human interleukin-10
Gesser B, et al.
Proceedings of the National Academy of Sciences of the USA, 94(26), 14620-14620 (1997)
IL-10: A Multifunctional Cytokine in Viral Infections
Rojas J, et al.
Journal of immunology research (2017)
Imbalance of Th22/Treg cells causes microinflammation in uremic patients undergoing hemodialysis
Ren T, et al.
Bioscience Reports, 39(10), 866-866 (2019)
TNF-a and IL10 polymorphisms interaction increases the risk of ankylosing spondylitis in Chinese Han population.
Wang NG
International Journal of Clinical and Experimental Pathology, 8(11), 15204-15209 (2015)
Investigation on the association between inerleukin-10 -592C/A, 819C/T and -1082A/G gene polymorphisms and development of diabetic nephrophathy.
Yin Q, et al.
International Journal of Clinical and Experimental Pathology, 8, 15216-15221 (2015)
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