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SAB4300883

Sigma-Aldrich

Anti-NeuN antibody produced in rabbit

affinity isolated antibody

Synonym(s):

FLJ56884, FLJ58356, FOX3, HRNBP3, RBFOX3

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1 EA
$597.00

$597.00

Available to ship onMarch 28, 2025Details

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1 EA
$597.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$597.00

Available to ship onMarch 28, 2025Details

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

34 kDa

species reactivity

human, mouse, rat

concentration

1.0 mg/mL

technique(s)

western blot: 1:500-1:2000 (Cell Lysate)

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Discovery® C18 HPLC Column 5 μm particle size, L × I.D. 25 cm × 4.6 mm

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Discovery® C18 HPLC Column

L × I.D.

5 cm × 2.1 mm

L × I.D.

5 cm × 4.6 mm

L × I.D.

15 cm × 4.6 mm

L × I.D.

25 cm × 4.6 mm

particle size

5 μm

particle size

5 μm

particle size

5 μm

particle size

5 μm

matrix active group

C18 (octadecyl) phase

matrix active group

C18 (octadecyl) phase

matrix active group

C18 (octadecyl) phase

matrix active group

C18 (octadecyl) phase

agency

suitable for USP L1

agency

suitable for USP L1

agency

suitable for USP L1

agency

suitable for USP L1

matrix

silica gel, high purity, spherical particle platform

matrix

silica gel, high purity, spherical particle platform

matrix

silica gel, high purity, spherical particle platform

matrix

silica gel, high purity, spherical particle platform

General description

NeuN (neuronal nuclei), also known as RBFOX3 (RNA binding protein, fox-1 homolog 3), is encoded by the gene mapped to human chromosome 17q25.3. The encoded protein belongs to the RBFOX family of proteins. NeuN is present in nuclei and perinuclear cytoplasm of most of the neurons in the central nervous system (CNS) of mammals.

Specificity

The antibody detects endogenous level of total NeuN protein.

Immunogen

Recombinant protein of human NeuN.

Application

Anti-NeuN antibody produced in rabbit has been used in Immunohistochemical staining.

Biochem/physiol Actions

NeuN (neuronal nuclei)/RBFOX3 (RNA binding protein, fox-1 homolog 3) is a RNA splicing factor. It controls neuronal splicing pathway. NeuN is used as a potential marker of postmitotic neurons in studies of neuronal differentiation and in the evaluation of neuronal status both in norm and pathology. Mutation in the gene is associated with risk of rolandic epilepsy. Studies have shown that in presence of neurological disorders, the protein is mislocalized.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    480132093

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    RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts.
    Li Y I, et al.
    Genome Research, 25(1), 1-13 (2015)
    Electroacupuncture promotes neural stem cell proliferation and neurogenesis in the dentate gyrus of rats following stroke via upregulation of Notch1 expression.
    Zhao J, et al.
    Molecular Medicine Reports, 12(5), 6911-6917 (2015)
    RBFOX1 and RBFOX3 mutations in rolandic epilepsy.
    Lal D, et al.
    PLoS ONE, 8(9), e73323-e73323 (2013)
    NeuN as a neuronal nuclear antigen and neuron differentiation marker.
    Gusel'Nikova V V and D E Korzhevskiy
    Acta Naturae, 7(2 (25)) (2015)
    Effect of transplantation of olfactory ensheathing cell conditioned medium induced bone marrow stromal cells on rats with spinal cord injury.
    Feng L, et al.
    Molecular Medicine Reports, 16(2), 1661-1668 (2017)
    View All Related Papers

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