Skip to Content
MilliporeSigma

[Efficacy of AboundTM for hand-foot syndrome caused by capecitabine].

Gan to kagaku ryoho. Cancer & chemotherapy (2014-01-08)
Chika Fujii, Hiroshi Imamura, Mutsumi Fukunaga, Shunji Kamigaki, Yutaka Kimura, Tomono Kawase, Ryohei Kawabata, Misako Fujino, Chihiro Iseki, Yoshiko Hamaguchi, Emiko Yamamoto, Toshihiko Ishizaka, Yoshimi Hachino
ABSTRACT

Hand-foot syndrome( HFS) has been reported to be the most common adverse effect of capecitabine, with an incidence of more than 50%. AboundTM, containing β-hydroxy-β-methyl butyric acid( HMB), L-glutamine, and L-arginine is effective in the treatment of decubitus ulcers and in wound healing; however, whether AboundTM is efficacious for HFS caused by capecitabine is not clear. This study aimed at evaluating the effectiveness of AboundTM in the recovery from HFS caused by capecitabine. Capecitabine administration was discontinued in 6 patients with more than grade 2 HFS, and AboundTM was administered. The time to recovery was examined. The median time to recovery to less than grade 1 HFS was 10 days( range, 4-14 days). The grade of HFS decreased following the administration of AboundTM. The findings of this study suggest that AboundTM is effective against HFS caused by capecitabine.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
L-Glutamine solution, 200 mM, solution, sterile-filtered, BioXtra, suitable for cell culture
Sigma-Aldrich
L-Glutamine solution, 200 mM, Hybri-Max, sterile-filtered, suitable for hybridoma
Sigma-Aldrich
Fluorouracil, meets USP testing specifications
SAFC
L-Glutamine Solution 200 mM, 29.23 mg/mL in saline, solution, suitable for cell culture
Sigma-Aldrich
5-Fluorouracil, ≥99% (HPLC), powder
Supelco
Fluorouracil, Pharmaceutical Secondary Standard; Certified Reference Material
Capecitabine, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Capecitabine, ≥98% (HPLC)
Sigma-Aldrich
2′-Deoxycytidine, ≥99% (HPLC)
Sigma-Aldrich
L-Glutamine, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
L-Glutamine, meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source
Sigma-Aldrich
L-Glutamine, γ-irradiated, BioXtra, suitable for cell culture
SAFC
L-Arginine
Sigma-Aldrich
L-Glutamine, BioUltra, ≥99.5% (NT)
Sigma-Aldrich
L-Arginine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%
SAFC
L-Glutamine
Supelco
L-Glutamine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Supelco
L-Glutamine, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
L-Arginine, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
L-Glutamine
Sigma-Aldrich
L-Arginine, 99%, FCC, FG
Sigma-Aldrich
L-Arginine, BioUltra, ≥99.5% (NT)
Sigma-Aldrich
L-Arginine, reagent grade, ≥98%