765309

金ナノ粒子

10 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H₂O

• 別名: 金コロイド
• UNSPSCコード: 12162002
• NACRES: NA.23

特性

• 物質: PEG 5000
• 品質水準: 100
• 形状: dispersion in H₂O; nanoparticles
• 包装: glass bottle of 1 mL
• OD: 50
• 直径: 10 nm
• pH: 6.0-8.0 (25 °C)
• 溶解性: water: miscible
• 密度: 1.00 g/cm³
• λmax: 520 nm
• 官能基: amine
• 保管温度: 2-8°C

詳細

詳細

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.

アプリケーション

Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Several other specific applications have been listed below:

• Since they adhere to cell membranes, AuNPs may be used in cellular and intracellular targeting in targeted drug delivery applications and can also be used in biodistribution studies
• AuNPs may also be used in photothermal therapy and radiotherapy
• Proposed applications of gold nanoparticles are as:drug delivery agents for cancer therapy, coatings, plastics, nanowire, nanofiber, textiles, catalyst applications.
• They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.

特徴および利点

• A negatively charged siRNA-PEG complex, attached to positively charged GNPs, is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.
• The PEG coating decreases the cytotoxicity and increases efficiency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable