902667

Propargyl-PEG6-acid

• 別名: 4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid, Propargyl-PEG6-CH2CO2H
• 実験式（ヒル表記法）: C₁₆H₂₈O₈
• CAS番号: 1951438-84-8
• 分子量: 348.39
• MDL番号: MFCD28950778
• UNSPSCコード: 12352106
• NACRES: NA.22

特性

• アッセイ: ≥95%
• フォーム: liquid
• 反応適合性: reaction type: click chemistry; reagent type: cross-linking reagent
• 屈折率: n/D 1.469
• 官能基: alkyne; carboxylic acid
• 保管温度: −20°C
• SMILES記法: OC(CCOCCOCCOCCOCCOCCOCC#C)=O
• InChI: 1S/C16H28O8/c1-2-4-19-6-8-21-10-12-23-14-15-24-13-11-22-9-7-20-5-3-16(17)18/h1H,3-15H2,(H,17,18)
• InChI Key: XRSJYQQOJNYUDV-UHFFFAOYSA-N

詳細

アプリケーション

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable